TGFBR1

Gene Symbol	TGFBR1
Entrez Gene	7046
Alt Symbol	AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I
Species	Human
Gene Type	protein-coding
Description	transforming growth factor, beta receptor 1
Other Description	TGF-beta receptor type-1|activin A receptor type II-like kinase, 53kDa|activin A receptor type II-like protein kinase of 53kD|activin receptor-like kinase 5|serine/threonine-protein kinase receptor R4|transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)|transforming growth factor-beta receptor type I
Swissprots	Q6IR47 P36897 Q706C1 Q706C0
Accessions	AAC08998 AAD02042 AAR32097 ABD46753 ACZ58375 CAZ91468 EAW58905 EAW58906 P36897 AJ420419 AJ619019 CAF02096 AJ619020 CAF02097 AK002171 AK129793 AK302059 BAG63449 AK302234 BAG63588 AL117597 BC038347 BC056247 BC071181 AAH71181 BX648917 EF142853 ABO93068 EF142854 ABO93069 L11695 AAA16073 XM_005252150 XP_005252207 XM_011518948 XP_011517250 XM_011518949 XP_011517251 XM_011518950 XP_011517252 NM_001130916 NP_001124388 NM_001306210 NP_001293139 NM_004612 NP_004603
Function	Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.
Tissue Specificity	Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
Top Pathways	TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, Colorectal cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TGF beta Receptor I (mutated T204 D) protein fragment - ab186088 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human TGF beta Receptor I protein fragment - ab105908 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human TGF beta Receptor I protein fragment - ab152746 from Abcam Category Protein Source Wheat germ Species Human

Human TGF beta Receptor I protein fragment - ab70837 from Abcam Category Protein Source Insect cells Species Human

TGFBR1 / ALK5 Antibody Blocking Peptide - LS-E3577 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TGFBR1 / ALK5 Antibody Blocking Peptide - LS-E27739 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TGFBR1 / ALK5 Antibody Blocking Peptide - LS-E9291 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TGF-beta RI/ALK-5 Protein - H00007046-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TGF-beta RI/ALK-5 Recombinant Protein - P4783 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

TGF-beta RI/ALK-5 Peptide - P2845 from Novus Biologicals Category Peptide Species Human

Mouse-Tgfbr1-Antibody-Center-Blocking-Peptide - BP14778c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg Species Mouse

TGF-Beta-Receptor-I-Antibody-Center-Blocking-peptide - BP7822c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human TGF-beta RI/ALK-5 Fc Chimera, CF - 3025-BR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human TGFBR1 Fc His tag protein - orb83591 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Human Species Human

Human TGFBR1 protein (GST Tag) - orb139731 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 50 μg, 100 μg Source Baculovirus-Insect Cells Species Human

TGFR1 Blocking Peptide - 33R-11051 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

ALK5 Blocking Peptide - abx063351 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Pig

Tgf beta Receptor I Peptide - AC21-2550-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TGFBR1 / ALK-5 - H00007046-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TGFBR1 / ALK-5 - H00007046-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TGFBR1 / ALK-5 - P4783 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

TGFBR1 Peptide - 42-356P from ProSci Category Peptide Species Mouse, Rat

Recombinant Human TGFBR1, Fc-His tagged - TGFBR1-2346H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human TGFBR1, GST-His - TGFBR1-716H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

Recombinant Human TGFBR1 - TGFBR1-31137TH from Creative Biomart Category Protein Source Baculovirus infected sf9 cells

Search more