| Gene Symbol |
ABCB11
|
| Entrez Gene |
8647
|
| Alt Symbol |
ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATP-binding cassette, sub-family B (MDR/TAP), member 11
|
| Other Description |
ABC member 16, MDR/TAP subfamily|ATP-binding cassette sub-family B member 11|bile salt export pump|progressive familial intrahepatic cholestasis 2|sister p-glycoprotein
|
| Swissprots |
O95342 Q9UNB2 Q53TL2
|
| Accessions |
AAY24100 AAY24305 CAI54162 CAI54163 EAX11285 EAX11286 EAX11287 O95342 AB012959 BAA88711 AF091582 AAC77455 AF136523 AAD28285 AK302540 BAG63812 AK303050 BAG64170 XM_006712817 XP_006712880 XM_011512077 XP_011510379 XM_011512078 XP_011510380 XM_011512079 XP_011510381 XM_011512080 XP_011510382 XM_011512081 XP_011510383 NM_003742 NP_003733
|
| Function |
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
|
| Top Pathways |
ABC transporters, Bile secretion
|