| Gene Symbol |
KCNE3
|
| Entrez Gene |
10008
|
| Alt Symbol |
HOKPP, HYPP, MiRP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, voltage gated subfamily E regulatory beta subunit 3
|
| Other Description |
cardiac voltage-gated potassium channel accessory subunit|minK-related peptide 2|minimum potassium ion channel-related peptide 2|potassium channel subunit beta MiRP2|potassium voltage-gated channel subfamily E member 3|potassium voltage-gated channel, Isk-related family, member 3|voltage-gated K+ channel subunit MIRP2
|
| Swissprots |
Q9Y6H6
|
| Accessions |
ABQ01240 EAW74938 Q9Y6H6 AF076531 AAD28089 AF302494 AAG16255 AK311876 BAG34817 BC032235 BC110612 AAI10613 BC113743 AAI13744 BM757131 CD709836 CK301015 CR457209 CAG33490 CR936625 CAI56768 DQ192291 ABB00304 DQ192292 ABB00305 DQ891015 ABM81941 DR006135 XM_011544713 XP_011543015 NM_005472 NP_005463
|
| Function |
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Widely expressed with highest levels in kidney and moderate levels in small intestine. {ECO:0000269|PubMed:10646604}.
|
| Top Pathways |
Protein digestion and absorption
|
![Western Blot: KCNE3 Overexpression Lysate (Adult Normal) [NBL1-12150] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCNE3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8698_KCNE3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12150-img0002.jpg)