Gene Symbol | RBM38 |
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Entrez Gene | 55544 |
Alt Symbol | HSRNASEB, RNPC1, SEB4B, SEB4D, dJ800J21.2 |
Species | Human |
Gene Type | protein-coding |
Description | RNA binding motif protein 38 |
Other Description | CLL-associated antigen KW-5|RNA-binding protein 38|RNA-binding region (RNP1, RRM) containing 1|RNA-binding region-containing protein 1|ssDNA-binding protein SEB4 |
Swissprots | Q9BYK4 Q9BYK3 A6NMU6 A6NDK1 Q15350 Q9H0Z9 Q15351 |
Accessions | EAW75520 EAW75521 EAW75522 Q9H0Z9 AF432218 AAL99924 BC018711 AAH18711 BE840212 BF371746 BM549757 DB504051 DN998561 DQ891994 ABM82920 DQ895184 ABM86110 X75314 CAA53063 XM_005260446 XP_005260503 XM_011528885 XP_011527187 NM_001291780 NP_001278709 NM_017495 NP_059965 NM_183425 NP_906270 |
Function | RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. {ECO:0000269|PubMed:17050675, ECO:0000269|PubMed:19285943}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:17050675}. Nucleus {ECO:0000269|PubMed:17050675}. |
RBM24/38 (G-6) - sc-393124 from Santa Cruz Biotechnology
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RBM24/38 (H-61) - sc-366519 from Santa Cruz Biotechnology
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RBM38 (A-8) - sc-365898 from Santa Cruz Biotechnology
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RBM38 (C-19) - sc-85873 from Santa Cruz Biotechnology
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RBM38 (P-13) - sc-85874 from Santa Cruz Biotechnology
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RBM38 (T-12) - sc-85875 from Santa Cruz Biotechnology
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Anti-RBM38 antibody - ab94420 from Abcam
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Anti-RBM38 antibody - ab168445 from Abcam
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Anti-RBM38 antibody - C-terminal - ab200403 from Abcam
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Anti-RBM38 Antibody (aa41-90) IHC-plus⢠- LS-B9690 from LifeSpan Bioscience
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Anti-RBM38 Antibody (C-Terminus) - LS-C110575 from LifeSpan Bioscience
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RNPC1 Antibody - NBP1-57503 from Novus Biologicals
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RNPC1 Antibody - H00055544-B02P from Novus Biologicals
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RBM38 Polyclonal Antibody - bs-7682R from Bioss
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Anti-RBM38 antibody produced in rabbit - AV40862 from Sigma-Aldrich
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Anti-RBM38 antibody produced in mouse - SAB1409498 from Sigma-Aldrich
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Anti-RBM38 antibody produced in rabbit - SAB2104556 from Sigma-Aldrich
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RBM38 antibody - N-terminal region (ARP40862_P050) - ARP40862_P050 from Aviva Systems Biology
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RBM38 antibody - middle region (ARP40863_P050) - ARP40863_P050 from Aviva Systems Biology
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RBM38 antibody - 70R-4915 from Fitzgerald
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RBM38 antibody - 70R-4914 from Fitzgerald
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RBM38 antibody - H00055544-B02P from Acris Antibodies
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Anti-RBM38 Antibody - AC11-0141 from Abcore
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RBM38 Antibody - 29-436 from ProSci
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RBM38 antibody - 16435-1-AP from Proteintech Group
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