RBM38
| Gene Symbol | RBM38 |
|---|---|
| Entrez Gene | 55544 |
| Alt Symbol | HSRNASEB, RNPC1, SEB4B, SEB4D, dJ800J21.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | RNA binding motif protein 38 |
| Other Description | CLL-associated antigen KW-5|RNA-binding protein 38|RNA-binding region (RNP1, RRM) containing 1|RNA-binding region-containing protein 1|ssDNA-binding protein SEB4 |
| Swissprots | Q9BYK4 Q9BYK3 A6NMU6 A6NDK1 Q15350 Q9H0Z9 Q15351 |
| Accessions | EAW75520 EAW75521 EAW75522 Q9H0Z9 AF432218 AAL99924 BC018711 AAH18711 BE840212 BF371746 BM549757 DB504051 DN998561 DQ891994 ABM82920 DQ895184 ABM86110 X75314 CAA53063 XM_005260446 XP_005260503 XM_011528885 XP_011527187 NM_001291780 NP_001278709 NM_017495 NP_059965 NM_183425 NP_906270 |
| Function | RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. {ECO:0000269|PubMed:17050675, ECO:0000269|PubMed:19285943}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:17050675}. Nucleus {ECO:0000269|PubMed:17050675}. |
RBM38 CRISPR/Cas9 KO Plasmid (h) - sc-403488 from Santa Cruz Biotechnology
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RBM38 HDR Plasmid (h) - sc-403488-HDR from Santa Cruz Biotechnology
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RBM38 Double Nickase Plasmid (h) - sc-403488-NIC from Santa Cruz Biotechnology
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RBM38 Double Nickase Plasmid (h2) - sc-403488-NIC-2 from Santa Cruz Biotechnology
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RBM38 CRISPR Activation Plasmid (h) - sc-403488-ACT from Santa Cruz Biotechnology
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RBM38 CRISPR Activation Plasmid (h2) - sc-403488-ACT-2 from Santa Cruz Biotechnology
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RBM38 Lentiviral Activation Particles (h) - sc-403488-LAC from Santa Cruz Biotechnology
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RBM38 Lentiviral Activation Particles (h2) - sc-403488-LAC-2 from Santa Cruz Biotechnology
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RBM38 siRNA (h) - sc-76368 from Santa Cruz Biotechnology
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RBM38 shRNA Plasmid (h) - sc-76368-SH from Santa Cruz Biotechnology
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RBM38 shRNA (h) Lentiviral Particles - sc-76368-V from Santa Cruz Biotechnology
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RNPC1 RNAi - H00055544-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN18043 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18043 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10359 from Sigma-Aldrich
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RBM38 siRNA (Human) - CRJ0734 from Cohesion Biosciences
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RNPC1 RNAi - H00055544-R02 from Novus Biologicals
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RBM38 - MBS8212784 from MyBioSource
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shRNA set against Human RBM38 (NM_017495.5) - SHH390740 from Creative biogene
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Human RBM38 siRNA - orb271235 from Biorbyt
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RBM38 shRNA Plasmid (Human) - CHJ0734 from Cohesion Biosciences
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RBM38 miRNA 3'UTR clone - MiUTR3H-12439 from Creative biogene
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RBM38 miRNA 3'UTR clone - MiUTR3H-12440 from Creative biogene
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