Gene Symbol | EDC3 |
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Entrez Gene | 80153 |
Alt Symbol | LSM16, YJDC, YJEFN2 |
Species | Human |
Gene Type | protein-coding |
Description | enhancer of mRNA decapping 3 |
Other Description | LSM16 homolog (EDC3, S. cerevisiae)|enhancer of mRNA decapping 3 homolog|enhancer of mRNA-decapping protein 3|hYjeF_N2|hYjeF_N2-15q23|yjeF N-terminal domain-containing protein 2|yjeF domain containing|yjeF domain-containing protein 1|yjeF_N2 |
Swissprots | Q9H797 D3DW61 Q96F86 B3KPH0 |
Accessions | EAW99316 EAW99317 EAW99318 EAW99319 Q96F86 AF193058 AAG22486 AK024781 BAB15001 AK056339 BAG51682 AK225099 AL133447 BC011534 AAH11534 BC021271 AAH21271 BM999594 CA440205 DA168050 DB007958 XM_011522091 XP_011520393 XM_011522092 XP_011520394 NM_001142443 NP_001135915 NM_001142444 NP_001135916 NM_025083 NP_079359 |
Function | Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:17533573, ECO:0000269|PubMed:18678652}. |
Subcellular Location | Cytoplasm, P-body {ECO:0000269|PubMed:16364915}. Note=Processing bodies (PB). |
Tissue Specificity | Expressed in theca and granulosa cells in ovary, and in spermatids of the meiotic division part II and apical membrane of Sertoli cells in testis (at protein level). Also expressed in brain and mammary gland. {ECO:0000269|PubMed:17533573}. |
Top Pathways | RNA degradation |
Edc3 CRISPR/Cas9 KO Plasmid (h) - sc-402917 from Santa Cruz Biotechnology
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Edc3 HDR Plasmid (h) - sc-402917-HDR from Santa Cruz Biotechnology
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Edc3 Double Nickase Plasmid (h) - sc-402917-NIC from Santa Cruz Biotechnology
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Edc3 Double Nickase Plasmid (h2) - sc-402917-NIC-2 from Santa Cruz Biotechnology
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Edc3 CRISPR Activation Plasmid (h) - sc-402917-ACT from Santa Cruz Biotechnology
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Edc3 CRISPR Activation Plasmid (h2) - sc-402917-ACT-2 from Santa Cruz Biotechnology
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Edc3 Lentiviral Activation Particles (h) - sc-402917-LAC from Santa Cruz Biotechnology
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Edc3 Lentiviral Activation Particles (h2) - sc-402917-LAC-2 from Santa Cruz Biotechnology
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Edc3 siRNA (h) - sc-62134 from Santa Cruz Biotechnology
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Edc3 shRNA Plasmid (h) - sc-62134-SH from Santa Cruz Biotechnology
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Edc3 shRNA (h) Lentiviral Particles - sc-62134-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU118491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7647 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7647 from Sigma-Aldrich
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EDC3 siRNA (Human) - CRJ2776 from Cohesion Biosciences
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EDC3 RNAi - H00080153-R01 from Novus Biologicals
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EDC3 - MBS8231244 from MyBioSource
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shRNA set against Human EDC3 (NM_025083.3) - SHH283085 from Creative biogene
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Human EDC3 siRNA - orb273277 from Biorbyt
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EDC3 shRNA Plasmid (Human) - CHJ2776 from Cohesion Biosciences
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EDC3 miRNA 3'UTR clone - MiUTR4H-TG02953 from Creative biogene
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