TRPA1
| Gene Symbol | TRPA1 |
|---|---|
| Entrez Gene | 8989 |
| Alt Symbol | ANKTM1, FEPS |
| Species | Human |
| Gene Type | protein-coding |
| Description | transient receptor potential cation channel, subfamily A, member 1 |
| Other Description | ankyrin-like with transmembrane domains 1|transformation-sensitive protein p120|transient receptor potential cation channel subfamily A member 1 |
| Swissprots | A6NIN6 O75762 |
| Accessions | EAW86986 O75762 AK307942 BC148423 AAI48424 BC153003 AAI53004 Y10601 CAA71610 XM_011517624 XP_011515926 XM_011517625 XP_011515927 NM_007332 NP_015628 |
| Function | Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells. {ECO:0000269|PubMed:10066796}. |
| Top Pathways | Inflammatory mediator regulation of TRP channels |
ANKTM1 (C-19) - sc-32353 from Santa Cruz Biotechnology
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ANKTM1 (C-4) - sc-166469 from Santa Cruz Biotechnology
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ANKTM1 (C-5) - sc-376495 from Santa Cruz Biotechnology
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ANKTM1 (H-155) - sc-66808 from Santa Cruz Biotechnology
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ANKTM1 (I-17) - sc-32351 from Santa Cruz Biotechnology
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Anti-TRPA1 antibody - ab58844 from Abcam
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Anti-TRPA1 antibody - ab62053 from Abcam
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Anti-TRPA1 antibody - ab75051 from Abcam
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Anti-TRPA1 antibody - ab68846 from Abcam
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Anti-TRPA1 antibody - ab56458 from Abcam
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Anti-TRPA1 Antibody (N-Terminus) - LS-C89802 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (4th Cytoplasmic Domain) - LS-C94992 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (aa1050-1120) - LS-C94994 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (N-Terminus) - LS-C95012 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (4th Cytoplasmic Domain) - LS-C95049 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (1st Cytoplasmic Domain) - LS-C95106 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (1st Cytoplasmic Domain) - LS-C95104 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (4th Cytoplasmic Domain) - LS-C95150 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (aa1050-1120) - LS-C95201 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (N-Terminus, Biotin) - LS-C141347 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (N-Terminus, DY488) - LS-C141349 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (N-Terminus, DY650) - LS-C141348 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (N-Terminus, DY550) - LS-C141351 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (N-Terminus, HRP) - LS-C141350 from LifeSpan Bioscience
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Anti-TRPA1 Antibody (aa539-588) - LS-C107881 from LifeSpan Bioscience
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