TRPA1

Gene Symbol	TRPA1
Entrez Gene	8989
Alt Symbol	ANKTM1, FEPS
Species	Human
Gene Type	protein-coding
Description	transient receptor potential cation channel, subfamily A, member 1
Other Description	ankyrin-like with transmembrane domains 1|transformation-sensitive protein p120|transient receptor potential cation channel subfamily A member 1
Swissprots	A6NIN6 O75762
Accessions	EAW86986 O75762 AK307942 BC148423 AAI48424 BC153003 AAI53004 Y10601 CAA71610 XM_011517624 XP_011515926 XM_011517625 XP_011515927 NM_007332 NP_015628
Function	Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). {ECO:0000250}.
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity	Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells. {ECO:0000269|PubMed:10066796}.
Top Pathways	Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat TRPA1 peptide - ab19805 from Abcam Category Peptide

TRPA1 peptide - ab150297 from Abcam Category Peptide

TRPA1 peptide - ab126555 from Abcam Category Peptide

TRPA1 Antibody Blocking Peptide - LS-E29559 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRPA1 Antibody Blocking Peptide - LS-E29560 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRPA1 Antibody Blocking Peptide - LS-E12522 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TRPA1 Protein - H00008989-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRPA1 Blocking Peptide - NB100-91319PEP from Novus Biologicals Category Peptide Prices $229.00 Sizes 50 µg Species Rat

TRPA1 Blocking Peptide - 33R-4277 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRPA1 - H00008989-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRPA1 - H00008989-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRPA1 fusion protein - Ag18685 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

TRPA1 fusion protein - ag18858 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human TRPA1, His-tagged - TRPA1-3431H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Transient Receptor Potential Cation Channel Subfamily A, Member 1 (TRPA1) - RPF831Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Transient Receptor Potential Cation Channel Subfamily A, Member 1 (TRPA1) - RPF831Hu01 from Cloud-clone Category Protein Source E.coli Species Human

TRPA1 peptide - ab204483 from Abcam Category Peptide

TRPA1 Recombinant Protein Antigen - NBP1-89075PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TRPA1 Peptide, Human - M34GP16670H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Transient receptor potential cation channel subfamily A member 1(TRPA1),partial - CSB-EP025074HU from Cusabio Category Protein Source E.coli Species Human

TRPA1 Recombinant Protein (OPCD07720) - OPCD07720 from Aviva Systems Biology Category Protein Source E.coli Species Human

Recombinant Human Transient receptor potential cation channel subfamily A member 1(TRPA1),partial - AP74482 from Signalway Antibody Category Protein Prices $155.00, $390.00, $665.00, $1,090.00, $1,835.00, $2,915.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

TRPA1 Recombinant Protein (Human) (OPCA04252) - OPCA04252 from Aviva Systems Biology Category Protein Species Human

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