TRPA1
| Gene Symbol | TRPA1 |
|---|---|
| Entrez Gene | 8989 |
| Alt Symbol | ANKTM1, FEPS |
| Species | Human |
| Gene Type | protein-coding |
| Description | transient receptor potential cation channel, subfamily A, member 1 |
| Other Description | ankyrin-like with transmembrane domains 1|transformation-sensitive protein p120|transient receptor potential cation channel subfamily A member 1 |
| Swissprots | A6NIN6 O75762 |
| Accessions | EAW86986 O75762 AK307942 BC148423 AAI48424 BC153003 AAI53004 Y10601 CAA71610 XM_011517624 XP_011515926 XM_011517625 XP_011515927 NM_007332 NP_015628 |
| Function | Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells. {ECO:0000269|PubMed:10066796}. |
| Top Pathways | Inflammatory mediator regulation of TRP channels |
ANKTM1 CRISPR/Cas9 KO Plasmid (h) - sc-402245 from Santa Cruz Biotechnology
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ANKTM1 HDR Plasmid (h) - sc-402245-HDR from Santa Cruz Biotechnology
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ANKTM1 Double Nickase Plasmid (h) - sc-402245-NIC from Santa Cruz Biotechnology
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ANKTM1 Double Nickase Plasmid (h2) - sc-402245-NIC-2 from Santa Cruz Biotechnology
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ANKTM1 CRISPR Activation Plasmid (h) - sc-402245-ACT from Santa Cruz Biotechnology
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ANKTM1 CRISPR Activation Plasmid (h2) - sc-402245-ACT-2 from Santa Cruz Biotechnology
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ANKTM1 Lentiviral Activation Particles (h) - sc-402245-LAC from Santa Cruz Biotechnology
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ANKTM1 Lentiviral Activation Particles (h2) - sc-402245-LAC-2 from Santa Cruz Biotechnology
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ANKTM1 siRNA (h) - sc-44780 from Santa Cruz Biotechnology
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ANKTM1 shRNA Plasmid (h) - sc-44780-SH from Santa Cruz Biotechnology
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ANKTM1 shRNA (h) Lentiviral Particles - sc-44780-V from Santa Cruz Biotechnology
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TRPA1 RNAi - H00008989-R01 from Novus Biologicals
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MISSION® esiRNA - EHU040601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22051 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10124 from Sigma-Aldrich
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TRPA1 siRNA (Human) - CRH5931 from Cohesion Biosciences
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TRPA1 - MBS8208285 from MyBioSource
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shRNA set against Human Trpa1 (NM_007332.2) - SHH435512 from Creative biogene
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shRNA set against Human TRPA1(NM_007332.2) - SHL096654 from Creative biogene
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TRPA1 shRNA Plasmid (Human) - CHH5931 from Cohesion Biosciences
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TRPA1 miRNA 3'UTR clone - MiUTR1H-10779 from Creative biogene
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