Gene Symbol | Grin3b |
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Entrez Gene | 170483 |
Alt Symbol | GluN3B, NR3B |
Species | Mouse |
Gene Type | protein-coding |
Description | glutamate receptor, ionotropic, NMDA3B |
Other Description | N-methyl-D-aspartate receptor subunit NR3B|NMDA receptor 4|NMDAR3B|glutamate [NMDA] receptor subunit 3B|glutamate receptor ionotropic, NMDA 3B|nr4 |
Swissprots | Q8VHV0 Q91ZU9 |
Accessions | EDL31619 Q91ZU9 AF373861 AAL40418 AF396649 AAL10018 AY062435 AAL38983 BC115747 AAI15748 BC152738 AAI52739 XM_006513287 XP_006513350 XM_006513288 XP_006513351 XM_006513289 XP_006513352 NM_130455 NP_569722 |
Function | NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:14602821}; Multi-pass membrane protein {ECO:0000269|PubMed:14602821}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:14602821}. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane. |
Tissue Specificity | Expressed in the facial nucleus and the ambiguus nucleus of the brainstem, pons, medulla, spinal cord and cerebellum. {ECO:0000269|PubMed:11717388, ECO:0000269|PubMed:12008020, ECO:0000269|PubMed:14602821}. |
Top Pathways | Glutamatergic synapse, Amphetamine addiction, Nicotine addiction, Cocaine addiction, Alcoholism |
NR3B CRISPR/Cas9 KO Plasmid (m) - sc-431267 from Santa Cruz Biotechnology
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NR3B HDR Plasmid (m) - sc-431267-HDR from Santa Cruz Biotechnology
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NR3B Double Nickase Plasmid (m) - sc-431267-NIC from Santa Cruz Biotechnology
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NR3B Double Nickase Plasmid (m2) - sc-431267-NIC-2 from Santa Cruz Biotechnology
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NR3B CRISPR Activation Plasmid (m) - sc-431267-ACT from Santa Cruz Biotechnology
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NR3B CRISPR Activation Plasmid (m2) - sc-431267-ACT-2 from Santa Cruz Biotechnology
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NR3B Lentiviral Activation Particles (m) - sc-431267-LAC from Santa Cruz Biotechnology
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NR3B Lentiviral Activation Particles (m2) - sc-431267-LAC-2 from Santa Cruz Biotechnology
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NR3B siRNA (m) - sc-62702 from Santa Cruz Biotechnology
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NR3B shRNA Plasmid (m) - sc-62702-SH from Santa Cruz Biotechnology
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NR3B shRNA (m) Lentiviral Particles - sc-62702-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN32850 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND32850 from Sigma-Aldrich
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GRIN3B siRNA (Mouse) - CRN1323 from Cohesion Biosciences
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GRIN3B - MBS8229666 from MyBioSource
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shRNA set against Mouse GRIN3B (NM_130455.2) - SHH307962 from Creative biogene
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shRNA set against Mouse Grin3b(NM_130455.2) - SHH104933 from Creative biogene
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Mouse GRIN3B siRNA - orb290798 from Biorbyt
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GRIN3B shRNA Plasmid (Mouse) - CHN1323 from Cohesion Biosciences
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GRIN3B miRNA 3'UTR clone - MiUTR1M-05383 from Creative biogene
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