EML1
| Gene Symbol | EML1 |
|---|---|
| Entrez Gene | 2009 |
| Alt Symbol | ELP79, EMAP, EMAPL, HuEMAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | echinoderm microtubule associated protein like 1 |
| Other Description | EMAP-1|echinoderm microtubule-associated protein-like 1|huEMAP-1 |
| Swissprots | Q8WWL6 O00423 Q8N536 Q86U15 Q8N5C4 |
| Accessions | CAD12600 EAW81679 EAW81680 EAW81681 O00423 AF035276 AK023861 AK126980 BAG54415 AK299812 BAH13136 AK307925 BC032541 AAH32541 BC033043 AAH33043 BX247979 CAD62313 BX420178 BX442035 DQ891556 ABM82482 DQ894743 ABM85669 U97018 AAB57824 XM_005267397 XP_005267454 XM_005267398 XP_005267455 XM_005267399 XP_005267456 XM_005267400 XP_005267457 XM_011536540 XP_011534842 XM_011536541 XP_011534843 XM_011536542 XP_011534844 NM_001008707 NP_001008707 NM_004434 NP_004425 |
| Function | Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Detected in cytoplasmic punctae. Co-localizes with microtubules. Enriched in perinuclear regions during interphase and in the region of spindle microtubules during metaphase. Enriched at the midzone during telophase and cytokinesis. Detected at growth cones in neurons (By similarity). {ECO:0000250}. |
| Tissue Specificity | Ubiquitous; expressed in most tissues with the exception of thymus and peripheral blood lymphocytes. {ECO:0000269|PubMed:10521658}. |
EML1 CRISPR/Cas9 KO Plasmid (h) - sc-406445 from Santa Cruz Biotechnology
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EML1 HDR Plasmid (h) - sc-406445-HDR from Santa Cruz Biotechnology
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EML1 Double Nickase Plasmid (h) - sc-406445-NIC from Santa Cruz Biotechnology
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EML1 Double Nickase Plasmid (h2) - sc-406445-NIC-2 from Santa Cruz Biotechnology
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EML1 CRISPR Activation Plasmid (h) - sc-406445-ACT from Santa Cruz Biotechnology
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EML1 CRISPR Activation Plasmid (h2) - sc-406445-ACT-2 from Santa Cruz Biotechnology
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EML1 Lentiviral Activation Particles (h) - sc-406445-LAC from Santa Cruz Biotechnology
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EML1 Lentiviral Activation Particles (h2) - sc-406445-LAC-2 from Santa Cruz Biotechnology
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EML1 siRNA (h) - sc-60576 from Santa Cruz Biotechnology
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EML1 shRNA Plasmid (h) - sc-60576-SH from Santa Cruz Biotechnology
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EML1 shRNA (h) Lentiviral Particles - sc-60576-V from Santa Cruz Biotechnology
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EML1 RNAi - H00002009-R02 from Novus Biologicals
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EML1 RNAi - H00002009-R01 from Novus Biologicals
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MISSION® esiRNA - EHU074781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7844 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7844 from Sigma-Aldrich
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EML1 siRNA (Human) - CRH1390 from Cohesion Biosciences
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EML1 - MBS8205439 from MyBioSource
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shRNA set against Human EML1 (NM_004434.2) - SHH285505 from Creative biogene
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shRNA set against Human EML1(NM_001008707.1) - SHH032483 from Creative biogene
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shRNA set against Human EML1(NM_004434.2) - SHH032555 from Creative biogene
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EML1 shRNA Plasmid (Human) - CHH1390 from Cohesion Biosciences
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EML1 miRNA 3'UTR clone - MiUTR1H-03212 from Creative biogene
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EML1 miRNA 3'UTR clone - MiUTR1H-03213 from Creative biogene
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