Gene Symbol | DLAT |
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Entrez Gene | 1737 |
Alt Symbol | DLTA, PDC-E2, PDCE2 |
Species | Human |
Gene Type | protein-coding |
Description | dihydrolipoamide S-acetyltransferase |
Other Description | 70 kDa mitochondrial autoantigen of primary biliary cirrhosis|E2 component of pyruvate dehydrogenase complex|M2 antigen complex 70 kDa subunit|PBC|dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex|dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial|dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial|pyruvate dehydrogenase complex component E2 |
Swissprots | Q53EP3 P10515 Q16783 |
Accessions | ACA05975 EAW67174 EAW67175 P10515 AF317200 AAG31658 AK057299 BAG51900 AK223596 BAD97316 AK296274 BAG58983 AK297103 BAG59614 AK299562 BAG61505 AK303930 BAG64858 AL832703 AW188637 BC039084 AAH39084 DB551427 DQ892447 ABM83373 DQ895658 ABM86584 X13822 CAA32052 Y00978 CAA68787 XM_011542647 XP_011540949 NM_001931 NP_001922 |
Function | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. |
Subcellular Location | Mitochondrion matrix. |
Top Pathways | Glycolysis / Gluconeogenesis, Citrate cycle (TCA cycle), Pyruvate metabolism, Carbon metabolism |
PDC-E2 CRISPR/Cas9 KO Plasmid (h) - sc-402520 from Santa Cruz Biotechnology
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PDC-E2 HDR Plasmid (h) - sc-402520-HDR from Santa Cruz Biotechnology
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PDC-E2 Double Nickase Plasmid (h) - sc-402520-NIC from Santa Cruz Biotechnology
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PDC-E2 Double Nickase Plasmid (h2) - sc-402520-NIC-2 from Santa Cruz Biotechnology
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PDC-E2 CRISPR Activation Plasmid (h) - sc-402520-ACT from Santa Cruz Biotechnology
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PDC-E2 CRISPR Activation Plasmid (h2) - sc-402520-ACT-2 from Santa Cruz Biotechnology
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PDC-E2 Lentiviral Activation Particles (h) - sc-402520-LAC from Santa Cruz Biotechnology
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PDC-E2 Lentiviral Activation Particles (h2) - sc-402520-LAC-2 from Santa Cruz Biotechnology
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PDC-E2 siRNA (h) - sc-40813 from Santa Cruz Biotechnology
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PDC-E2 shRNA Plasmid (h) - sc-40813-SH from Santa Cruz Biotechnology
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PDC-E2 shRNA (h) Lentiviral Particles - sc-40813-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU029881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2033 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2033 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09085 from Sigma-Aldrich
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DLAT siRNA (Human) - CRH1205 from Cohesion Biosciences
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DLAT - MBS8213805 from MyBioSource
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shRNA set against Human DLAT (NM_001931.4) - SHH278397 from Creative biogene
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DLAT shRNA Plasmid (Human) - CHH1205 from Cohesion Biosciences
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DLAT miRNA 3'UTR clone - MiUTR3H-10217 from Creative biogene
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