Gene Symbol | CDC42BPG |
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Entrez Gene | 55561 |
Alt Symbol | DMPK2, HSMDPKIN, KAPPA-200, MRCKG, MRCKgamma |
Species | Human |
Gene Type | protein-coding |
Description | CDC42 binding protein kinase gamma (DMPK-like) |
Other Description | CDC42-binding protein kinase gamma|DMPK-like gamma|MRCK gamma|myotonic dystrophy kinase-related CDC42-binding kinase gamma|myotonic dystrophy protein kinase like protein|myotonic dystrophy protein kinase-like alpha|myotonic dystrophy protein kinase-like gamma|serine/threonine-protein kinase MRCK gamma |
Swissprots | O00565 Q6DT37 |
Accessions | CAF05454 EAW74316 Q6DT37 AY648038 AAT67172 BI793270 Y12337 CAA73006 XM_011545155 XP_011543457 XM_011545156 XP_011543458 XM_011545157 XP_011543459 XM_011545158 XP_011543460 XM_011545159 XP_011543461 XM_011545160 XP_011543462 XM_011545161 XP_011543463 XR_949988 XR_949989 NM_017525 NP_059995 |
Function | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15194684}. Note=Concentrates at the leading edge of cells. |
Tissue Specificity | Expressed in heart and skeletal muscle. {ECO:0000269|PubMed:15194684}. |
MRCKγ CRISPR/Cas9 KO Plasmid (h) - sc-406697 from Santa Cruz Biotechnology
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MRCKγ HDR Plasmid (h) - sc-406697-HDR from Santa Cruz Biotechnology
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MRCKγ Double Nickase Plasmid (h) - sc-406697-NIC from Santa Cruz Biotechnology
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MRCKγ Double Nickase Plasmid (h2) - sc-406697-NIC-2 from Santa Cruz Biotechnology
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MRCKγ CRISPR Activation Plasmid (h) - sc-406697-ACT from Santa Cruz Biotechnology
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MRCKγ CRISPR Activation Plasmid (h2) - sc-406697-ACT-2 from Santa Cruz Biotechnology
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MRCKγ Lentiviral Activation Particles (h) - sc-406697-LAC from Santa Cruz Biotechnology
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MRCKγ Lentiviral Activation Particles (h2) - sc-406697-LAC-2 from Santa Cruz Biotechnology
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MRCKγ siRNA (h) - sc-96278 from Santa Cruz Biotechnology
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MRCKγ shRNA Plasmid (h) - sc-96278-SH from Santa Cruz Biotechnology
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MRCKγ shRNA (h) Lentiviral Particles - sc-96278-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU133201 from Sigma-Aldrich
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MISSION® siRNA - SIHK0331 from Sigma-Aldrich
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MISSION® siRNA - SIHK0329 from Sigma-Aldrich
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MISSION® siRNA - SIHK0330 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5785 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5785 from Sigma-Aldrich
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CDC42BPG siRNA (Human) - CRJ0741 from Cohesion Biosciences
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CDC42BPG RNAi - H00055561-R02 from Novus Biologicals
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CDC42BPG - MBS8235440 from MyBioSource
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MRCKγ CRISPR/Cas9 KO Plasmid (h2) - sc-406697-KO-2 from Santa Cruz Biotechnology
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MRCKγ HDR Plasmid (h2) - sc-406697-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CDC42BPG (NM_017525.2) - SHH259845 from Creative biogene
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Human CDC42BPG siRNA - orb271242 from Biorbyt
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CDC42BPG shRNA Plasmid (Human) - CHJ0741 from Cohesion Biosciences
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