| Gene Symbol | CNGA1 |
|---|---|
| Entrez Gene | 1259 |
| Alt Symbol | CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclic nucleotide gated channel alpha 1 |
| Other Description | CNG channel alpha-1|cGMP-gated cation channel alpha-1|cyclic nucleotide-gated cation channel 1|cyclic nucleotide-gated channel alpha-1|cyclic nucleotide-gated channel, photoreceptor|interleukin-1 homologue|rod photoreceptor cGMP-gated channel subunit alpha |
| Swissprots | Q4W5E3 Q16485 Q16279 J3KPZ2 A8K7K6 P29973 |
| Accessions | AAD14206 AAY40919 EAW93048 EAW93049 P29973 AK292021 BAF84710 BC140399 AAI40400 M84741 AAA52010 S42457 AAB22778 W89170 W93472 X64802 CAA46027 XM_005248049 XP_005248106 XM_011513623 XP_011511925 NM_000087 NP_000078 NM_001142564 NP_001136036 |
| Function | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Rod cells in the retina. |
| Top Pathways | Phototransduction, cGMP-PKG signaling pathway, cAMP signaling pathway |