Gene Symbol | CNGA1 |
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Entrez Gene | 1259 |
Alt Symbol | CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49 |
Species | Human |
Gene Type | protein-coding |
Description | cyclic nucleotide gated channel alpha 1 |
Other Description | CNG channel alpha-1|cGMP-gated cation channel alpha-1|cyclic nucleotide-gated cation channel 1|cyclic nucleotide-gated channel alpha-1|cyclic nucleotide-gated channel, photoreceptor|interleukin-1 homologue|rod photoreceptor cGMP-gated channel subunit alpha |
Swissprots | Q4W5E3 Q16485 Q16279 J3KPZ2 A8K7K6 P29973 |
Accessions | AAD14206 AAY40919 EAW93048 EAW93049 P29973 AK292021 BAF84710 BC140399 AAI40400 M84741 AAA52010 S42457 AAB22778 W89170 W93472 X64802 CAA46027 XM_005248049 XP_005248106 XM_011513623 XP_011511925 NM_000087 NP_000078 NM_001142564 NP_001136036 |
Function | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Rod cells in the retina. |
Top Pathways | Phototransduction, cGMP-PKG signaling pathway, cAMP signaling pathway |
CNG-1 CRISPR/Cas9 KO Plasmid (h) - sc-403946 from Santa Cruz Biotechnology
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CNG-1 HDR Plasmid (h) - sc-403946-HDR from Santa Cruz Biotechnology
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CNG-1 Double Nickase Plasmid (h) - sc-403946-NIC from Santa Cruz Biotechnology
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CNG-1 Double Nickase Plasmid (h2) - sc-403946-NIC-2 from Santa Cruz Biotechnology
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CNG-1 CRISPR Activation Plasmid (h) - sc-403946-ACT from Santa Cruz Biotechnology
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CNG-1 CRISPR Activation Plasmid (h2) - sc-403946-ACT-2 from Santa Cruz Biotechnology
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CNG-1 Lentiviral Activation Particles (h) - sc-403946-LAC from Santa Cruz Biotechnology
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CNG-1 Lentiviral Activation Particles (h2) - sc-403946-LAC-2 from Santa Cruz Biotechnology
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CNG-1 siRNA (h) - sc-42391 from Santa Cruz Biotechnology
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CNG-1 shRNA Plasmid (h) - sc-42391-SH from Santa Cruz Biotechnology
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CNG-1 shRNA (h) Lentiviral Particles - sc-42391-V from Santa Cruz Biotechnology
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CNG1 RNAi - H00001259-R01 from Novus Biologicals
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MISSION® esiRNA - EHU054671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1925 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1925 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05069 from Sigma-Aldrich
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CNGA1 siRNA (Human) - CRH0879 from Cohesion Biosciences
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CNGA1 - MBS8205257 from MyBioSource
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shRNA set against Human CNGA1 (NM_000087.3) - SHH266153 from Creative biogene
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Human CNGA1 siRNA - orb261381 from Biorbyt
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CNGA1 shRNA Plasmid (Human) - CHH0879 from Cohesion Biosciences
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CNGA1 miRNA 3'UTR clone - MiUTR3H-00570 from Creative biogene
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CNGA1 miRNA 3'UTR clone - MiUTR3H-00571 from Creative biogene
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