| Gene Symbol |
CNGA1
|
| Entrez Gene |
1259
|
| Alt Symbol |
CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclic nucleotide gated channel alpha 1
|
| Other Description |
CNG channel alpha-1|cGMP-gated cation channel alpha-1|cyclic nucleotide-gated cation channel 1|cyclic nucleotide-gated channel alpha-1|cyclic nucleotide-gated channel, photoreceptor|interleukin-1 homologue|rod photoreceptor cGMP-gated channel subunit alpha
|
| Swissprots |
Q4W5E3 Q16485 Q16279 J3KPZ2 A8K7K6 P29973
|
| Accessions |
AAD14206 AAY40919 EAW93048 EAW93049 P29973 AK292021 BAF84710 BC140399 AAI40400 M84741 AAA52010 S42457 AAB22778 W89170 W93472 X64802 CAA46027 XM_005248049 XP_005248106 XM_011513623 XP_011511925 NM_000087 NP_000078 NM_001142564 NP_001136036
|
| Function |
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Rod cells in the retina.
|
| Top Pathways |
Phototransduction, cGMP-PKG signaling pathway, cAMP signaling pathway
|