| Gene Symbol |
KCTD12
|
| Entrez Gene |
115207
|
| Alt Symbol |
C13orf2, PFET1, PFETIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel tetramerization domain containing 12
|
| Other Description |
BTB/POZ domain-containing protein KCTD12|potassium channel tetramerisation domain containing 12|predominantly fetal expressed T1 domain
|
| Swissprots |
Q96CX2
|
| Accessions |
EAW80558 Q96CX2 AF052169 AF359381 AAQ15187 AK057635 AK128363 BAG54666 BC013764 AAH13764 BU742274 DB153209 NM_138444 NP_612453
|
| Function |
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
|
| Tissue Specificity |
Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung. {ECO:0000269|PubMed:15357420}.
|