Gene Symbol | KCTD12 |
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Entrez Gene | 115207 |
Alt Symbol | C13orf2, PFET1, PFETIN |
Species | Human |
Gene Type | protein-coding |
Description | potassium channel tetramerization domain containing 12 |
Other Description | BTB/POZ domain-containing protein KCTD12|potassium channel tetramerisation domain containing 12|predominantly fetal expressed T1 domain |
Swissprots | Q96CX2 |
Accessions | EAW80558 Q96CX2 AF052169 AF359381 AAQ15187 AK057635 AK128363 BAG54666 BC013764 AAH13764 BU742274 DB153209 NM_138444 NP_612453 |
Function | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
Subcellular Location | Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. |
Tissue Specificity | Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung. {ECO:0000269|PubMed:15357420}. |
KCTD12 CRISPR/Cas9 KO Plasmid (h) - sc-406882 from Santa Cruz Biotechnology
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KCTD12 HDR Plasmid (h) - sc-406882-HDR from Santa Cruz Biotechnology
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KCTD12 Double Nickase Plasmid (h) - sc-406882-NIC from Santa Cruz Biotechnology
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KCTD12 Double Nickase Plasmid (h2) - sc-406882-NIC-2 from Santa Cruz Biotechnology
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KCTD12 CRISPR Activation Plasmid (h) - sc-406882-ACT from Santa Cruz Biotechnology
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KCTD12 CRISPR Activation Plasmid (h2) - sc-406882-ACT-2 from Santa Cruz Biotechnology
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KCTD12 Lentiviral Activation Particles (h) - sc-406882-LAC from Santa Cruz Biotechnology
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KCTD12 Lentiviral Activation Particles (h2) - sc-406882-LAC-2 from Santa Cruz Biotechnology
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KCTD12 siRNA (h) - sc-75374 from Santa Cruz Biotechnology
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KCTD12 shRNA Plasmid (h) - sc-75374-SH from Santa Cruz Biotechnology
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KCTD12 shRNA (h) Lentiviral Particles - sc-75374-V from Santa Cruz Biotechnology
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KCTD12 RNAi - H00115207-R01 from Novus Biologicals
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MISSION® esiRNA - EHU121831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11002 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11002 from Sigma-Aldrich
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KCTD12 siRNA (Human) - CRJ4434 from Cohesion Biosciences
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shRNA set against Human KCTD12 (NM_138444.3) - SHH323855 from Creative biogene
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shRNA set against Human KCTD12(NM_138444.3) - SHL193032 from Creative biogene
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Human KCTD12 siRNA - orb274935 from Biorbyt
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KCTD12 shRNA Plasmid (Human) - CHJ4434 from Cohesion Biosciences
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KCTD12 miRNA 3'UTR clone - MiUTR1H-05174 from Creative biogene
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