| Gene Symbol | CLIC1 |
|---|---|
| Entrez Gene | 1192 |
| Alt Symbol | G6, NCC27 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chloride intracellular channel 1 |
| Other Description | RNCC protein|chloride channel ABP|chloride intracellular channel protein 1|hRNCC|nuclear chloride ion channel 27|nuclear chloride ion channel protein|p64CLCP|regulatory nuclear chloride ion channel protein |
| Swissprots | O00299 Q502X1 Q15089 |
| Accessions | AAD18073 BAB63376 CAB46078 EAX03503 EAX03504 EAX03505 O00299 AF034607 AAD20437 AF109197 AAD26137 AI192421 AK129773 AK223379 BAD97099 AK314014 BAG36725 BC064527 AAH64527 BC095469 AAH95469 BM562536 CB124154 CR542071 CAG46868 CX783058 HY057217 U93205 AAC25675 X87689 CAA61020 NM_001287593 NP_001274522 NM_001287594 NP_001274523 NM_001288 NP_001279 |
| Function | Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. {ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:11195932, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:9139710}. |
| Subcellular Location | Nucleus. Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. |
| Tissue Specificity | Expression is prominent in heart, placenta, liver, kidney and pancreas. {ECO:0000269|PubMed:10793131}. |