Gene Symbol | NSD1 |
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Entrez Gene | 64324 |
Alt Symbol | ARA267, KMT3B, SOTOS, SOTOS1, STO |
Species | Human |
Gene Type | protein-coding |
Description | nuclear receptor binding SET domain protein 1 |
Other Description | H3-K36-HMTase|H4-K20-HMTase|NR-binding SET domain-containing protein|androgen receptor coactivator 267 kDa protein|androgen receptor-associated coregulator 267|androgen receptor-associated protein of 267 kDa|histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific|lysine N-methyltransferase 3B|nuclear receptor-binding SET domain-containing protein 1 |
Swissprots | Q96RN7 Q96PD8 Q96L73 |
Accessions | CCO13784 EAW85031 EAW85032 EAW85033 Q96L73 AF085858 AF322907 AAK92049 AF380302 AAL27991 AF395588 AAL40694 AK001546 AK025916 BAB15281 AK026066 BAB15346 AK055187 BAB70868 AK056667 BAB71247 AK091358 BAC03645 AK126591 AL832983 CAH56331 AY049721 AAL06645 BC021961 AAH21961 BC139789 AAI39790 BC144629 BC150628 AAI50629 CK300021 CN333750 XM_005265959 XP_005266016 XM_005265960 XP_005266017 XM_005265961 XP_005266018 XM_005265962 XP_005266019 XM_011534610 XP_011532912 XM_011534611 XP_011532913 XM_011534612 XP_011532914 XM_011534613 XP_011532915 XM_011534614 XP_011532916 XM_011534615 XP_011532917 XM_011534616 XP_011532918 XM_011534617 XP_011532919 NM_022455 NP_071900 NM_172349 NP_758859 |
Function | Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
Subcellular Location | Nucleus. Chromosome {ECO:0000305}. |
Tissue Specificity | Expressed in the fetal/adult brain, kidney, skeletal muscle, spleen, and the thymus, and faintly in the lung. |
Top Pathways | Lysine degradation |
NSD1 (C-15) - sc-46016 from Santa Cruz Biotechnology
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NSD1 (D-20) - sc-32479 from Santa Cruz Biotechnology
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NSD1 (N-15) - sc-46018 from Santa Cruz Biotechnology
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NSD1 (N-20) - sc-32475 from Santa Cruz Biotechnology
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NSD1 (K47) - sc-130470 from Santa Cruz Biotechnology
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Anti-KMT3B / NSD1 antibody - ab89432 from Abcam
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Anti-KMT3B / NSD1 antibody - ab84137 from Abcam
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Anti-KMT3B / NSD1 antibody [2658C1a] - ab70732 from Abcam
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Anti-NSD1 Antibody (clone 2658C1a) - LS-C342683 from LifeSpan Bioscience
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Anti-NSD1 Antibody (aa650-700) - LS-C286303 from LifeSpan Bioscience
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Anti-NSD1 Antibody (aa650-700) - LS-C73730 from LifeSpan Bioscience
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Anti-NSD1 Antibody - LS-C73731 from LifeSpan Bioscience
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Anti-NSD1 Antibody (clone 4F1) - LS-C139162 from LifeSpan Bioscience
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Anti-NSD1 Antibody (clone 3E6) - LS-C139536 from LifeSpan Bioscience
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Anti-NSD1 Antibody (clone 2658C1a) - LS-C184648 from LifeSpan Bioscience
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Anti-NSD1 Antibody - LS-C178312 from LifeSpan Bioscience
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Anti-NSD1 Antibody (aa2-110, Azide-free) - LS-C328059 from LifeSpan Bioscience
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KMT3B/NSD1 Antibody - NB100-1744 from Novus Biologicals
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KMT3B/NSD1 Antibody (4F1) - H00064324-M08 from Novus Biologicals
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KMT3B/NSD1 Antibody - H00064324-A01 from Novus Biologicals
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KMT3B/NSD1 Antibody (1C12) - H00064324-M05 from Novus Biologicals
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NSD1 Polyclonal Antibody - bs-8170R from Bioss
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Monoclonal Anti-NSD1 antibody produced in mouse - WH0064324M5 from Sigma-Aldrich
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Monoclonal Anti-NSD1 antibody produced in mouse - SAB1405251 from Sigma-Aldrich
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NSD1-Antibody-monoclonal-M08 - AT3117a from Abgent, a WuXi AppTec company
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