Gene Symbol | APLNR |
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Entrez Gene | 187 |
Alt Symbol | AGTRL1, APJ, APJR, HG11 |
Species | Human |
Gene Type | protein-coding |
Description | apelin receptor |
Other Description | APJ (apelin) receptor|APJ receptor|G protein-coupled receptor APJ|G-protein coupled receptor APJ|G-protein coupled receptor HG11|HG11 orphan receptor|angiotensin II receptor-like 1|angiotensin receptor-like 1 |
Swissprots | P35414 |
Accessions | AAA18954 EAW73730 P35414 AK074514 BAC11032 AK075252 BAG52096 AK097232 BAG53437 AK315542 BAG37920 AL548962 AL553350 BC032688 AAH32688 BI004477 BM698661 BX439288 DQ890844 ABM81770 EU176506 ABW03307 X89271 CAA61546 NM_005161 NP_005152 NR_027991 |
Function | Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon. |
Top Pathways | Neuroactive ligand-receptor interaction |
APLNR (C-17) - sc-33838 from Santa Cruz Biotechnology
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APLNR (H-300) - sc-33823 from Santa Cruz Biotechnology
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APLNR (Y-18) - sc-73713 from Santa Cruz Biotechnology
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Anti-APJ Receptor antibody - ab66218 from Abcam
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Anti-APJ Receptor antibody - ab97452 from Abcam
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Anti-APJ Receptor antibody - ab97464 from Abcam
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Anti-APJ Receptor antibody - Cytoplasmic domain - ab140508 from Abcam
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Anti-APLNR/ Apelin Receptor / APJ Antibody - LS-C96392 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody - LS-C149246 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody - LS-C109292 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (aa357-377, Biotin) - LS-C183754 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (aa357-377, CF) - LS-C183755 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (aa357-377) - LS-C190488 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (aa46-95) - LS-C135685 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (aa214-244, AP) - LS-C251526 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (aa214-244, APC) - LS-C251527 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (aa214-244, FITC) - LS-C251528 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (aa214-244, Azide-free, HRP) - LS-C251529 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (C-Terminus) IHC-plus⢠- LS-B8252 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (aa214-244, PE) - LS-C251530 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (aa214-244) - LS-C329225 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (Biotin) - LS-C343579 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (aa215-244) - LS-C156413 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody (aa284-376) - LS-C185364 from LifeSpan Bioscience
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Anti-APLNR/ Apelin Receptor / APJ Antibody - LS-C155715 from LifeSpan Bioscience
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