| Gene Symbol |
APLNR
|
| Entrez Gene |
187
|
| Alt Symbol |
AGTRL1, APJ, APJR, HG11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apelin receptor
|
| Other Description |
APJ (apelin) receptor|APJ receptor|G protein-coupled receptor APJ|G-protein coupled receptor APJ|G-protein coupled receptor HG11|HG11 orphan receptor|angiotensin II receptor-like 1|angiotensin receptor-like 1
|
| Swissprots |
P35414
|
| Accessions |
AAA18954 EAW73730 P35414 AK074514 BAC11032 AK075252 BAG52096 AK097232 BAG53437 AK315542 BAG37920 AL548962 AL553350 BC032688 AAH32688 BI004477 BM698661 BX439288 DQ890844 ABM81770 EU176506 ABW03307 X89271 CAA61546 NM_005161 NP_005152 NR_027991
|
| Function |
Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|
![Western Blot: Apelin receptor Overexpression Lysate (Adult Normal) [NBL1-07606] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Apelin receptor.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12005_Apelin%2520receptor%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-07606-img0002.jpg)