| Gene Symbol | APLNR |
|---|---|
| Entrez Gene | 187 |
| Alt Symbol | AGTRL1, APJ, APJR, HG11 |
| Species | Human |
| Gene Type | protein-coding |
| Description | apelin receptor |
| Other Description | APJ (apelin) receptor|APJ receptor|G protein-coupled receptor APJ|G-protein coupled receptor APJ|G-protein coupled receptor HG11|HG11 orphan receptor|angiotensin II receptor-like 1|angiotensin receptor-like 1 |
| Swissprots | P35414 |
| Accessions | AAA18954 EAW73730 P35414 AK074514 BAC11032 AK075252 BAG52096 AK097232 BAG53437 AK315542 BAG37920 AL548962 AL553350 BC032688 AAH32688 BI004477 BM698661 BX439288 DQ890844 ABM81770 EU176506 ABW03307 X89271 CAA61546 NM_005161 NP_005152 NR_027991 |
| Function | Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon. |
| Top Pathways | Neuroactive ligand-receptor interaction |