SLC12A5

Gene Symbol SLC12A5
Entrez Gene 57468
Alt Symbol KCC2
Species Human
Gene Type protein-coding
Description solute carrier family 12 (potassium/chloride transporter), member 5
Other Description K-Cl cotransporter 2|electroneutral potassium-chloride cotransporter 2|erythroid K-Cl cotransporter 2|hKCC2|neuronal K-Cl cotransporter|solute carrier family 12 member 5
Swissprots Q9H4Z0 Q9H2X9 Q5VZ41 A2RTX2 Q9ULP4
Accessions EAW75771 EAW75772 EAW75773 Q9H2X9 AB033002 BAA86490 AF208159 AAG43493 AK055066 AK098371 AK289758 BAF82447 AK294059 BAH11662 AK295096 BAH11972 AK295900 BAH12216 AK296331 BAH12319 BC036329 BC132668 AAI32669 BC132670 AAI32671 DA102113 DC320473 KC295693 AGH06150 KC295694 AGH06151 KC295695 AGH06152 KC295696 AGH06153 KC295697 AGH06154 KC295698 AGH06155 KC295699 AGH06156 KC295700 AGH06157 KC295701 AGH06158 U79245 NM_001134771 NP_001128243 NM_020708 NP_065759
Function Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Brain specific. Detected in neuronal cells.
Top Pathways GABAergic synapse

KCC2 (H-57) - sc-367096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
KCC2 (H-57): sc-367096. Western blot analysis of KCC2 expression in mouse brain tissue extract (A) and K-562 whole cell lysate (B).

KCC2 (R-14) - sc-19420 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KCC2 (R-14): sc-19420. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing cytoplasmic staining of cells in germinal and non-germinal centers.

KCC2a (E-13) - sc-139371 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

KCC2a (S-14) - sc-139369 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

KCC2b (L-17) - sc-139370 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-KCC2 antibody - ab97502 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KCC2 antibody (ab97502) at 1 µg/mlLane 1 : Brain (Rat) Tissue LysateLane 2 : Rat Cortex Tissue Lysate Lane 3 : Rat Hippocampus Tissue LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-KCC2 antibody - ab107452 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-KCC2 antibody (ab107452) at 1/100 dilution + K562 cell lysate at 35 µg

Anti-KCC2 antibody - ab99129 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KCC2 antibody (ab99129) at 1 µg/ml + Human fetal spleen lysate at 10 µg

Anti-KCC2 antibody [N1/66] - ab174936 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone N1/66
Anti-KCC2 antibody [N1/66] (ab174936) at 5 µg/ml + Rat Cortex Tissue Lysate at 20 µgSecondaryGoat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/10000 dilutionPerformed under reducing conditions.

Anti-KCC2 antibody [S1-12] - ab134300 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12
Overlay histogram showing SH-SY5Y cells stained with ab134300 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab134300, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was an anti-mouse Alexa Fluor® 488 (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in SH-SY5Y cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-KCC2 antibody [S1-12] (Biotin) - ab183428 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12

Anti-KCC2 antibody [S1-12] (FITC) - ab183426 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12

Anti-KCC2 antibody [S1-12] (HRP) - ab183427 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12

Anti-SLC12A5 / KCC2 Antibody (aa932-1043, clone S1-12, Atto 390) - LS-C231603 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12

Anti-SLC12A5 / KCC2 Antibody (aa932-1043, clone S1-12, Atto 565) - LS-C231607 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12

Anti-SLC12A5 / KCC2 Antibody (aa932-1043, clone S1-12, Atto 488) - LS-C231608 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12

Anti-SLC12A5 / KCC2 Antibody (aa932-1043, clone S1-12, Atto 594) - LS-C231609 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12

Anti-SLC12A5 / KCC2 Antibody (aa932-1043, clone S1-12, Atto 633) - LS-C231610 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12

Anti-SLC12A5 / KCC2 Antibody (aa932-1043, clone S1-12, Atto 680) - LS-C231611 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12

Anti-SLC12A5 / KCC2 Antibody (N-Terminus) - LS-C135150 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLC12A5 / KCC2 antibody LS-C135150 Western blot of Mouse Brain lysate. Antibody concentration 1 ug/ml.

Anti-SLC12A5 / KCC2 Antibody (aa932-1043, clone S1-12, Atto 655) - LS-C231612 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12

Anti-SLC12A5 / KCC2 Antibody (aa971-1020) - LS-C110846 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLC12A5 / KCC2 antibody LS-C110846 Western blot of Fetal Spleen lysate.

Anti-SLC12A5 / KCC2 Antibody (aa932-1043, clone S1-12, Atto 700) - LS-C231613 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12

Anti-SLC12A5 / KCC2 Antibody (aa932-1043, clone S1-12, AP) - LS-C231614 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12

Anti-SLC12A5 / KCC2 Antibody (aa932-1043, clone S1-12, APC) - LS-C231615 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1-12
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