| Gene Symbol |
SLC12A5
|
| Entrez Gene |
57468
|
| Alt Symbol |
KCC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 12 (potassium/chloride transporter), member 5
|
| Other Description |
K-Cl cotransporter 2|electroneutral potassium-chloride cotransporter 2|erythroid K-Cl cotransporter 2|hKCC2|neuronal K-Cl cotransporter|solute carrier family 12 member 5
|
| Swissprots |
Q9H4Z0 Q9H2X9 Q5VZ41 A2RTX2 Q9ULP4
|
| Accessions |
EAW75771 EAW75772 EAW75773 Q9H2X9 AB033002 BAA86490 AF208159 AAG43493 AK055066 AK098371 AK289758 BAF82447 AK294059 BAH11662 AK295096 BAH11972 AK295900 BAH12216 AK296331 BAH12319 BC036329 BC132668 AAI32669 BC132670 AAI32671 DA102113 DC320473 KC295693 AGH06150 KC295694 AGH06151 KC295695 AGH06152 KC295696 AGH06153 KC295697 AGH06154 KC295698 AGH06155 KC295699 AGH06156 KC295700 AGH06157 KC295701 AGH06158 U79245 NM_001134771 NP_001128243 NM_020708 NP_065759
|
| Function |
Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Brain specific. Detected in neuronal cells.
|
| Top Pathways |
GABAergic synapse
|
![Western Blot: SLC12A5 Overexpression Lysate (Adult Normal) [NBL1-16006] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLC12A5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1526_SLC12A5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16006-img0002.jpg)