| Gene Symbol |
PRG3
|
| Entrez Gene |
10394
|
| Alt Symbol |
MBP2, MBPH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteoglycan 3
|
| Other Description |
eosinophil major basic protein homolog|prepro-MBPH|prepro-major basic protein homolog
|
| Swissprots |
Q9Y2Y8
|
| Accessions |
AAG41952 EAW73738 Q9Y2Y8 AF132209 AAD24471 AY358930 AAQ89289 BC069126 AAH69126 BC101613 AAI01614 BC113411 AAI13412 HQ258112 ADR82866 NM_006093 NP_006084
|
| Function |
Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. {ECO:0000269|PubMed:10318872}.
|
| Subcellular Location |
Cytoplasmic granule {ECO:0000269|PubMed:10318872}. Note=Localized to the eosinophil secondary granule.
|
| Tissue Specificity |
Expressed in bone marrow. Not detected in placenta. {ECO:0000269|PubMed:10318872}.
|