Gene Symbol | PRG3 |
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Entrez Gene | 10394 |
Alt Symbol | MBP2, MBPH |
Species | Human |
Gene Type | protein-coding |
Description | proteoglycan 3 |
Other Description | eosinophil major basic protein homolog|prepro-MBPH|prepro-major basic protein homolog |
Swissprots | Q9Y2Y8 |
Accessions | AAG41952 EAW73738 Q9Y2Y8 AF132209 AAD24471 AY358930 AAQ89289 BC069126 AAH69126 BC101613 AAI01614 BC113411 AAI13412 HQ258112 ADR82866 NM_006093 NP_006084 |
Function | Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. {ECO:0000269|PubMed:10318872}. |
Subcellular Location | Cytoplasmic granule {ECO:0000269|PubMed:10318872}. Note=Localized to the eosinophil secondary granule. |
Tissue Specificity | Expressed in bone marrow. Not detected in placenta. {ECO:0000269|PubMed:10318872}. |
MBPH CRISPR/Cas9 KO Plasmid (h) - sc-411465 from Santa Cruz Biotechnology
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MBPH HDR Plasmid (h) - sc-411465-HDR from Santa Cruz Biotechnology
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MBPH Double Nickase Plasmid (h) - sc-411465-NIC from Santa Cruz Biotechnology
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MBPH Double Nickase Plasmid (h2) - sc-411465-NIC-2 from Santa Cruz Biotechnology
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MBPH CRISPR Activation Plasmid (h) - sc-411465-ACT from Santa Cruz Biotechnology
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MBPH CRISPR Activation Plasmid (h2) - sc-411465-ACT-2 from Santa Cruz Biotechnology
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MBPH Lentiviral Activation Particles (h) - sc-411465-LAC from Santa Cruz Biotechnology
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MBPH Lentiviral Activation Particles (h2) - sc-411465-LAC-2 from Santa Cruz Biotechnology
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MBPH siRNA (h) - sc-96304 from Santa Cruz Biotechnology
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MBPH shRNA Plasmid (h) - sc-96304-SH from Santa Cruz Biotechnology
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MBPH shRNA (h) Lentiviral Particles - sc-96304-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU046891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17397 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17397 from Sigma-Aldrich
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PRG3 siRNA (Human) - CRH7043 from Cohesion Biosciences
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shRNA set against Human PRG3 (NM_006093.3) - SHH382492 from Creative biogene
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Human PRG3 siRNA - orb267545 from Biorbyt
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PRG3 shRNA Plasmid (Human) - CHH7043 from Cohesion Biosciences
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PRG3 miRNA 3'UTR clone - MiUTR3H-08739 from Creative biogene
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