Igf1r

Gene Symbol	Igf1r
Entrez Gene	16001
Alt Symbol	A330103N21Rik, CD221, D930020L01, IGF-1R, hyft
Species	Mouse
Gene Type	protein-coding
Description	insulin-like growth factor I receptor
Other Description	IGF-I receptor|insulin-like growth factor 1 receptor|line 186
Swissprots	Q62123 Q60751 O70438
Accessions	Q60751 AB006442 BAA21790 AF056187 AAC12782 AK020732 AK044980 AK051086 AK054320 AK086316 AK087668 AK135205 AK137220 BAE23276 AK155079 AK155884 BAE33482 AK162325 BC027571 BC062186 BC138868 AAI38869 BC138869 AAI38870 BE655570 BE982844 BP755056 CF540517 M33422 AAA40013 U00182 AAC52123 XM_006540641 XP_006540704 XM_006540642 XP_006540705 XM_006540643 XP_006540706 XM_006540644 XP_006540707 XM_006540645 XP_006540708 NM_010513 NP_034643
Function	Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downs
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Top Pathways	Focal adhesion, Long-term depression, Proteoglycans in cancer, Rap1 signaling pathway, Melanoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse Igf1r / Insulin-like Growth Factor 1 Receptor ELISA Kit - RAB0800 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Insulin-like growth factor 1 receptor (IGF1R), Mouse, ELISA Kit - E03I0430 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Insulin-like growth factor 1 receptor, Igf1r, Mouse, ELISA Kit - E1200m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Insulin-like growth factors 1 receptor (IGF-1R), Mouse, ELISA Kit - CSB-E15987m from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Custom Mouse IGF-1R ELISA - ELM-IGF1R from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

insulin-like growth factor 1 receptor, ELISA Kit - MBS705678 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

insulin-like growth factors 1 receptor, IGF-1R, ELISA Kit - MBS9301243 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse insulin-like growth factors 1 receptor(IGF-1R)ELISA Kit - CSB-E15987m from Cusabio Category ELISA Kit Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

ELISA Kit for Insulin Like Growth Factor 1 Receptor (IGF1R) - SEB659Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.054ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse IGF1R ELISA Kit - abx154177 from Abbexa Category ELISA Kit Sensitivity 0.057 ng/ml Range 0.156 ng/ml - 10 ng/ml

Custom Mouse IGF-1R ELISA Kit - orb159021 from Biorbyt Category ELISA Kit Prices $1,148.00, $1,981.00, $4,284.00 Sizes 96 well, 192 assays, 480 assays

Custom Mouse IGF-1R ELISA - ELM-IGF1R-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Mouse Igf1r ELISA Kit - E056716 from Biobool Category ELISA Kit

IGF1R ELISA Kit (Mouse) (OKCD02613) - OKCD02613 from Aviva Systems Biology Category ELISA Kit Prices $535.00 Sizes 10 ng Sensitivity 0.056 ng/mL Range 0.156-10 ng/mL

Insulin-like growth factor 1 receptor, ELISA Kit - MBS288699 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse IGF1R ELISA Kit - orb409493 from Biorbyt Category ELISA Kit

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