| Gene Symbol |
Igf1r
|
| Entrez Gene |
16001
|
| Alt Symbol |
A330103N21Rik, CD221, D930020L01, IGF-1R, hyft
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
insulin-like growth factor I receptor
|
| Other Description |
IGF-I receptor|insulin-like growth factor 1 receptor|line 186
|
| Swissprots |
Q62123 Q60751 O70438
|
| Accessions |
Q60751 AB006442 BAA21790 AF056187 AAC12782 AK020732 AK044980 AK051086 AK054320 AK086316 AK087668 AK135205 AK137220 BAE23276 AK155079 AK155884 BAE33482 AK162325 BC027571 BC062186 BC138868 AAI38869 BC138869 AAI38870 BE655570 BE982844 BP755056 CF540517 M33422 AAA40013 U00182 AAC52123 XM_006540641 XP_006540704 XM_006540642 XP_006540705 XM_006540643 XP_006540706 XM_006540644 XP_006540707 XM_006540645 XP_006540708 NM_010513 NP_034643
|
| Function |
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downs
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Top Pathways |
Focal adhesion, Long-term depression, Proteoglycans in cancer, Rap1 signaling pathway, Melanoma
|