Igf1r

Gene Symbol	Igf1r
Entrez Gene	16001
Alt Symbol	A330103N21Rik, CD221, D930020L01, IGF-1R, hyft
Species	Mouse
Gene Type	protein-coding
Description	insulin-like growth factor I receptor
Other Description	IGF-I receptor|insulin-like growth factor 1 receptor|line 186
Swissprots	Q62123 Q60751 O70438
Accessions	Q60751 AB006442 BAA21790 AF056187 AAC12782 AK020732 AK044980 AK051086 AK054320 AK086316 AK087668 AK135205 AK137220 BAE23276 AK155079 AK155884 BAE33482 AK162325 BC027571 BC062186 BC138868 AAI38869 BC138869 AAI38870 BE655570 BE982844 BP755056 CF540517 M33422 AAA40013 U00182 AAC52123 XM_006540641 XP_006540704 XM_006540642 XP_006540705 XM_006540643 XP_006540706 XM_006540644 XP_006540707 XM_006540645 XP_006540708 NM_010513 NP_034643
Function	Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downs
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Top Pathways	Focal adhesion, Long-term depression, Proteoglycans in cancer, Rap1 signaling pathway, Melanoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

SignalSilence ® IGF-I Receptor β siRNA I (Mouse Specific) - 12482 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

SignalSilence ® IGF-I Receptor β siRNA II (Mouse Specific) - 12595 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

IGF-IRα/β siRNA (m) - sc-35638 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

IGF-IRα/β shRNA Plasmid (m) - sc-35638-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

IGF-IRα/β shRNA (m) Lentiviral Particles - sc-35638-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU017201 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN33682 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33682 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

IGF1R siRNA (Mouse) - CRM2012 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

IGF1R - MBS8228150 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse IGF1R (NM_010513.2) - SHH317449 from Creative biogene Category siRNA Species Reactivities Mouse

shRNA set against Mouse Igf1r(NM_010513.2) - SHL167898 from Creative biogene Category siRNA Species Reactivities Mouse

Mouse IGF1R siRNA - orb281488 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

IGF1R shRNA Plasmid (Mouse) - CHM2012 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

IGF1R miRNA 3'UTR clone - MiUTR1M-05938 from Creative biogene Species Reactivities Mouse

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