| Gene Symbol |
TMED2
|
| Entrez Gene |
10959
|
| Alt Symbol |
P24A, RNP24, p24
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transmembrane emp24 domain trafficking protein 2
|
| Other Description |
coated vesicle membrane protein|membrane protein p24A|p24 family protein beta-1|p24beta1|transmembrane emp24 domain-containing protein 2
|
| Swissprots |
Q15363
|
| Accessions |
EAW98417 EAW98418 Q15363 AK024976 AK298167 BAG60439 AK303189 BAG64282 AK312975 BAG35812 BC025957 AAH25957 BI086507 CR541663 CAG46464 CR541682 CAG46483 X92098 CAA63069 XM_005253544 XP_005253601 NM_006815 NP_006806
|
| Function |
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase- activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Gol
|
| Subcellular Location |
Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway.
|