TMED2

Gene Symbol	TMED2
Entrez Gene	10959
Alt Symbol	P24A, RNP24, p24
Species	Human
Gene Type	protein-coding
Description	transmembrane emp24 domain trafficking protein 2
Other Description	coated vesicle membrane protein|membrane protein p24A|p24 family protein beta-1|p24beta1|transmembrane emp24 domain-containing protein 2
Swissprots	Q15363
Accessions	EAW98417 EAW98418 Q15363 AK024976 AK298167 BAG60439 AK303189 BAG64282 AK312975 BAG35812 BC025957 AAH25957 BI086507 CR541663 CAG46464 CR541682 CAG46483 X92098 CAA63069 XM_005253544 XP_005253601 NM_006815 NP_006806
Function	Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase- activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Gol
Subcellular Location	Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TMED2 full length protein - ab161217 from Abcam Category Protein Source Wheat germ Species Human

TMED2 Antibody Blocking Peptide - LS-E2218 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TMED2 Antibody Blocking Peptide - LS-E24201 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TMED2 Protein - H00010959-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TMED2-Antibody-N-term-Blocking-Peptide - BP13140a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HIV-1 p17/ p24/ gp120 protein - orb85297 from Biorbyt Category Protein Prices $383.00, $1,292.00 Sizes 100 μg, 1 mg

HIV-1 gag p17, p24 protein - orb81717 from Biorbyt Category Protein Prices $323.00, $595.00, $1,139.00 Sizes 100 μg, 500 μg, 1000 μg

HIV p24 His tag protein - orb83803 from Biorbyt Category Protein Prices $196.00, $281.00, $434.00, $612.00 Sizes 5 μg, 20 μg, 50 μg, 100 μg Source E. coli

HIV-1 p17/p24 protein - orb85296 from Biorbyt Category Protein Prices $383.00 Sizes 100 μg

HIV-1 p17/ p24/ gp120/ gp41 protein - orb85298 from Biorbyt Category Protein Prices $383.00, $1,292.00 Sizes 100 μg, 1 mg

HIV1 p24 protein - 30-1336 from Fitzgerald Category Protein Prices $265.00 Sizes 1 mg Source E.coli

HIV1 p24 protein - 30-AH24 from Fitzgerald Category Protein Prices $275.00 Sizes 1 mg Source E.coli

HIV1 p24 protein - 30R-AH028 from Fitzgerald Category Protein Prices $295.00 Sizes 100 µg Source E.coli

HIV1 p24 protein - 30-014001 from Fitzgerald Category Protein Prices $461.00 Sizes 100 µg Source Baculovirus

HIV1 p24 protein - 30-014101 from Fitzgerald Category Protein Prices $460.00 Sizes 100 µg Source E.coli

HIV1 p24 protein (FITC) - 65-014003 from Fitzgerald Category Protein Prices $525.00 Sizes 50 µg Source Baculovirus

HIV1 p24 protein (His tag) - 30-AH79 from Fitzgerald Category Protein Prices $341.00 Sizes 100 µg Source Yeast

HIV1 p24 protein (His tag) - 80-1358 from Fitzgerald Category Protein Prices $95.00, $595.00 Sizes 100 µg, 1 mg Source E.coli

HIV1 p24 protein (His tag) - 30R-AH029 from Fitzgerald Category Protein Prices $195.00, $1,295.00, $4,395.00 Sizes 100 µg, 1 mg, 5 mg Source Yeast

HIV1 p24 protein (HRP) - 65-014002 from Fitzgerald Category Protein Prices $525.00 Sizes 50 µg Source Baculovirus

p24 (HIV-1/HXBc2) - P5080 from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg

p24 - P4912 from Acris Antibodies Category Protein Prices $580.00 Sizes 100 µg

TMED2 / RNP24 - H00010959-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TMED2 / RNP24 - H00010959-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human immunodeficiency virus 1 p24 - 230-00505-10 from RayBiotech Category Protein Prices $110.00 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

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