Gene Symbol | HSD17B2 |
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Entrez Gene | 3294 |
Alt Symbol | EDH17B2, HSD17, SDR9C2 |
Species | Human |
Gene Type | protein-coding |
Description | hydroxysteroid (17-beta) dehydrogenase 2 |
Other Description | 17-beta-HSD 2|17-beta-hydroxysteroid dehydrogenase type 2|20 alpha-hydroxysteroid dehydrogenase|20-alpha-HSD|E2DH|estradiol 17-beta-dehydrogenase 2|microsomal 17-beta-hydroxysteroid dehydrogenase|short chain dehydrogenase/reductase family 9C member 2|short chain dehydrogenase/reductase family 9C, member 2|testosterone 17-beta-dehydrogenase |
Swissprots | B2R7T4 P37059 |
Accessions | AAC41917 AAP78485 EAW95519 P37059 AK223001 BAD96721 AK313109 BAG35931 AU139034 BC009581 AAH09581 BC059170 AAH59170 BM670647 BP270993 DQ893100 ABM84026 DQ896372 ABM87371 L11708 AAA03562 XR_243405 NM_002153 NP_002144 |
Function | Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Top Pathways | Steroid hormone biosynthesis, Ovarian steroidogenesis |
17β-HSD2 siRNA (h) - sc-61914 from Santa Cruz Biotechnology
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17β-HSD2 shRNA Plasmid (h) - sc-61914-SH from Santa Cruz Biotechnology
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17β-HSD2 shRNA (h) Lentiviral Particles - sc-61914-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU050001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10327 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10327 from Sigma-Aldrich
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HSD17B2 siRNA (Human) - CRH2251 from Cohesion Biosciences
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HSD17B2 - MBS8239422 from MyBioSource
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shRNA set against Human HSD17B2 (NM_002153.2) - SHH315201 from Creative biogene
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Human HSD17B2 siRNA - orb262753 from Biorbyt
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HSD17B2 shRNA Plasmid (Human) - CHH2251 from Cohesion Biosciences
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HSD17B2 miRNA 3'UTR clone - MiUTR3H-00255 from Creative biogene
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