LAIR1

Gene Symbol	LAIR1
Entrez Gene	3903
Alt Symbol	CD305, LAIR-1
Species	Human
Gene Type	protein-coding
Description	leukocyte-associated immunoglobulin-like receptor 1
Other Description	leukocyte-associated Ig-like receptor 1
Swissprots	Q6GTX8
Accessions	EAW72233 EAW72234 EAW72235 EAW72236 EAW72237 EAW72238 Q6GTX8 AF013249 AAB69324 AF109683 AAF17107 AF251509 AAF71274 AF251510 AAF71275 AK093559 AK097869 BAG53543 AK290415 BAF83104 AK303261 BAG64343 AK309895 AK315419 BAG37808 BC027899 AAH27899 BI756388 BM918573 CA435919 CR542051 CAG46848 DA419411 DA462442 DA941174 DB134342 DB143367 DC379147 DC389365 DC390481 DC391314 DQ892072 ABM82998 DQ895266 ABM86192 HY279173 XM_005258920 XP_005258977 XM_005258924 XP_005258981 XM_005277111 XP_005277168 XM_005277309 XP_005277366 XM_006726158 XP_006726221 XM_011526960 XP_011525262 XM_011547528 XP_011545830 XM_011548614 XP_011546916 NM_001289023 NP_001275952 NM_001289025 NP_001275954 NM_001289026 NP_001275955 NM_001289027 NP_001275956 NM_002287 NP_002278 NM_021706 NP_068352 NR_110279 NR_110280 NM_021708
Function	Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down- regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. {ECO:0000269|PubMed:102
Subcellular Location	Cell membrane {ECO:0000269|PubMed:10229813, ECO:0000269|PubMed:11160222, ECO:0000269|PubMed:9285412}; Single- pass type I membrane protein {ECO:0000269|PubMed:10229813, ECO:0000269|PubMed:11160222, ECO:0000269|PubMed:9285412}.
Tissue Specificity	Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection. {ECO:0000269|PubMed:10540327, ECO:0000269|PubMed:12757266, ECO:0000269|PubMed:14604962, ECO:0000269|PubMed:15950745}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LAIR1 / CD305 ELISA Kit (Sandwich ELISA) - LS-F8135 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.129 ng/ml Range 0.313-20 ng/ml

Human LAIR1 / CD305 ELISA Kit (Sandwich ELISA) - LS-F11912 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.313-20 ng/ml

Human LAIR1 ELISA Kit - abx152153 from Abbexa Category ELISA Kit Sensitivity 0.122 ng/ml Range 0.313 ng/ml - 20 ng/ml

Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1), Human, ELISA Kit - SEB004Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.109ng/mL Range 0.312-20ng/mL

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), Human, ELISA Kit - CSB-EL012721HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Leukocyte-associated immunoglobulin-like receptor 1, LAIR1, Human, ELISA Kit - E9027h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.156-10 ng/mL

LAIR1 (Human) IP-WB Antibody Pair - H00003903-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

LAIR1 (Human) Matched Antibody Pair - H00003903-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

LAIR1 (Human) Matched Antibody Pair - H00003903-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1), ELISA Kit - MBS2023241 from MyBioSource Category ELISA Kit Prices $355.00, $540.00, $730.00, $2,985.00, $5,410.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.129ng/mL. Range 0.313-20ng/mL

leukocyte-associated immunoglobulin-like receptor 1, ELISA Kit - MBS921819 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) - SEB004Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.129ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Leukocyte-associated immunoglobulin-like receptor 1(LAIR1) ELISA kit - CSB-EL012721HU from Cusabio Category ELISA Kit Sensitivity Request Information Range Request Information

ELISA Kit for Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) - SEB004Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.129ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Mouse LAIR1 / CD305 ELISA Kit (Sandwich ELISA) - LS-F20285 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.313-20 ng/ml

Rat LAIR1 / CD305 ELISA Kit (Custom ELISA) - LS-F20286 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Custom Human LAIR1 ELISA - ELH-LAIR1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Leukocyte-associated immunoglobulin-like receptor 1 ELISA Kit - abx251789 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1), Human, ELISA Kit - DL-LAIR1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Custom Human LAIR1 Elisa kit - orb305320 from Biorbyt Category ELISA Kit Prices $1,148.00, $1,981.00, $4,284.00 Sizes 96 assays, 192 assays, 480 assays

Human LAIR1 ELISA Kit - orb369609 from Biorbyt Category ELISA Kit Prices $527.00, $604.00 Sizes 48 test, 96 test Range Detection Range: 0.313-20ng/mL Detection low threshold: 0.109ng/mL

Human LAIR1 ELISA Kit - abx572770 from Abbexa Category ELISA Kit Sensitivity 0.109 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human LAIR1 ELISA - RAB1553 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

Human Leukocyte-associated immunoglobulin-like receptor 1(LAIR1) ELISA Kit - EKC34424 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,287.50 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.195 ng/ml Range 0.78 ng/ml-50 ng/ml

Human Leukocyte-associated immunoglobulin-like receptor 1 ELISA Kit - EKE54539 from Biomatik Category ELISA Kit Prices $759.00, $3,225.75, $6,072.00 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.067 ng/mL Range 0.156-10 ng/mL

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