LAIR1

Gene Symbol	LAIR1
Entrez Gene	3903
Alt Symbol	CD305, LAIR-1
Species	Human
Gene Type	protein-coding
Description	leukocyte-associated immunoglobulin-like receptor 1
Other Description	leukocyte-associated Ig-like receptor 1
Swissprots	Q6GTX8
Accessions	EAW72233 EAW72234 EAW72235 EAW72236 EAW72237 EAW72238 Q6GTX8 AF013249 AAB69324 AF109683 AAF17107 AF251509 AAF71274 AF251510 AAF71275 AK093559 AK097869 BAG53543 AK290415 BAF83104 AK303261 BAG64343 AK309895 AK315419 BAG37808 BC027899 AAH27899 BI756388 BM918573 CA435919 CR542051 CAG46848 DA419411 DA462442 DA941174 DB134342 DB143367 DC379147 DC389365 DC390481 DC391314 DQ892072 ABM82998 DQ895266 ABM86192 HY279173 XM_005258920 XP_005258977 XM_005258924 XP_005258981 XM_005277111 XP_005277168 XM_005277309 XP_005277366 XM_006726158 XP_006726221 XM_011526960 XP_011525262 XM_011547528 XP_011545830 XM_011548614 XP_011546916 NM_001289023 NP_001275952 NM_001289025 NP_001275954 NM_001289026 NP_001275955 NM_001289027 NP_001275956 NM_002287 NP_002278 NM_021706 NP_068352 NR_110279 NR_110280 NM_021708
Function	Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down- regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. {ECO:0000269|PubMed:102
Subcellular Location	Cell membrane {ECO:0000269|PubMed:10229813, ECO:0000269|PubMed:11160222, ECO:0000269|PubMed:9285412}; Single- pass type I membrane protein {ECO:0000269|PubMed:10229813, ECO:0000269|PubMed:11160222, ECO:0000269|PubMed:9285412}.
Tissue Specificity	Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection. {ECO:0000269|PubMed:10540327, ECO:0000269|PubMed:12757266, ECO:0000269|PubMed:14604962, ECO:0000269|PubMed:15950745}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LAIR1 protein fragment - ab151673 from Abcam Category Protein Source HEK 293 cells Species Human

Human LAIR1 protein fragment - ab51219 from Abcam Category Protein Source E. coli Species Human

LAIR1 / CD305 Antibody Blocking Peptide - LS-E2705 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LAIR1 / CD305 Antibody Blocking Peptide - LS-E27287 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LAIR1 / CD305 Antibody Blocking Peptide - LS-E24020 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LAIR1 / CD305 Antibody Blocking Peptide - LS-E24019 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LAIR1 Partial Recombinant Protein - H00003903-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

LAIR1 Recombinant Protein - H00003903-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 25 ug 10 ug Species Human

Recombinant Human LAIR1 Protein - NBC1-18412 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Source E.coli Species Human

LAIR1 Recombinant Protein - H00003903-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

LAIR1-Antibody-Center-Blocking-peptide - BP13784c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LAIR1 blocking peptide - GTX88141-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human LAIR1, CF - 2664-LR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln22-His163, with a C-terminal 6-His tag

LAIR1 Protein (OPPA01341) - OPPA01341 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

LAIR-1 protein - orb197695 from Biorbyt Category Protein Prices $255.00, $391.00, $519.00 Sizes 10 μg, 50 μg, 100 μg Species Human

Human LAIR1 protein - orb81191 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Goat anti LAIR1 antibody Immunizing peptide - orb59760 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

LAIR1 protein - 30R-1033 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

Human LAIR1 Protein - abx067773 from Abbexa Category Protein Source E.coli Species Human

LAIR1 Peptide - AC21-2107-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CD305 - H00003903-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

CD305 / LAIR1 (22-125) - SA6036 from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

CD305 / LAIR1 (22-125) - SA6036X from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

CD305 / LAIR1 - H00003903-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD305 / LAIR1 - H00003903-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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