| Gene Symbol | LAIR1 |
|---|---|
| Entrez Gene | 3903 |
| Alt Symbol | CD305, LAIR-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | leukocyte-associated immunoglobulin-like receptor 1 |
| Other Description | leukocyte-associated Ig-like receptor 1 |
| Swissprots | Q6GTX8 |
| Accessions | EAW72233 EAW72234 EAW72235 EAW72236 EAW72237 EAW72238 Q6GTX8 AF013249 AAB69324 AF109683 AAF17107 AF251509 AAF71274 AF251510 AAF71275 AK093559 AK097869 BAG53543 AK290415 BAF83104 AK303261 BAG64343 AK309895 AK315419 BAG37808 BC027899 AAH27899 BI756388 BM918573 CA435919 CR542051 CAG46848 DA419411 DA462442 DA941174 DB134342 DB143367 DC379147 DC389365 DC390481 DC391314 DQ892072 ABM82998 DQ895266 ABM86192 HY279173 XM_005258920 XP_005258977 XM_005258924 XP_005258981 XM_005277111 XP_005277168 XM_005277309 XP_005277366 XM_006726158 XP_006726221 XM_011526960 XP_011525262 XM_011547528 XP_011545830 XM_011548614 XP_011546916 NM_001289023 NP_001275952 NM_001289025 NP_001275954 NM_001289026 NP_001275955 NM_001289027 NP_001275956 NM_002287 NP_002278 NM_021706 NP_068352 NR_110279 NR_110280 NM_021708 |
| Function | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down- regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. {ECO:0000269|PubMed:102 |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:10229813, ECO:0000269|PubMed:11160222, ECO:0000269|PubMed:9285412}; Single- pass type I membrane protein {ECO:0000269|PubMed:10229813, ECO:0000269|PubMed:11160222, ECO:0000269|PubMed:9285412}. |
| Tissue Specificity | Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection. {ECO:0000269|PubMed:10540327, ECO:0000269|PubMed:12757266, ECO:0000269|PubMed:14604962, ECO:0000269|PubMed:15950745}. |