Gene Symbol | ADRA2A |
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Entrez Gene | 150 |
Alt Symbol | ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32 |
Species | Human |
Gene Type | protein-coding |
Description | adrenoceptor alpha 2A |
Other Description | adrenergic, alpha-2A-, receptor|alpha-2 adrenergic receptor subtype C10|alpha-2-adrenergic receptor, platelet type|alpha-2A adrenergic receptor|alpha-2A adrenoceptor|alpha-2A adrenoreceptor|alpha-2AAR subtype C10 |
Swissprots | Q86TH8 P08913 Q2I8G2 Q2XN99 B0LPF6 Q9BZK1 |
Accessions | AAA51664 AAA51665 AAF91441 AAG00447 AAK01634 AAK51162 AAZ73101 ABB72683 ABY87535 EAW49547 P08913 AF284095 AAK26743 BC035047 AAH35047 BC050414 AAH50414 BM682651 NM_000681 NP_000672 |
Function | Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:23105096}; Multi-pass membrane protein {ECO:0000269|PubMed:23105096}. |
Top Pathways | cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction |
α 2A -AR (H-150) - sc-28983 from Santa Cruz Biotechnology
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α 2A -AR (T-15) - sc-31357 from Santa Cruz Biotechnology
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α 2A -AR (C-19) - sc-1478 from Santa Cruz Biotechnology
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α 2A -AR (G-14) - sc-31356 from Santa Cruz Biotechnology
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Anti-alpha 2a Adrenergic Receptor antibody - ab65833 from Abcam
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Anti-ADRA2A Antibody (aa281-330) - LS-C120551 from LifeSpan Bioscience
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Anti-ADRA2A Antibody (C-Terminus, Sepharose) - LS-C171639 from LifeSpan Bioscience
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Anti-ADRA2A Antibody (C-Terminus, Magnetic beads) - LS-C171638 from LifeSpan Bioscience
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Anti-ADRA2A Antibody (aa324-373) - LS-C151378 from LifeSpan Bioscience
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Anti-ADRA2A Antibody (C-Terminus) - LS-C171637 from LifeSpan Bioscience
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Anti-ADRA2A Antibody (aa213-228) - LS-C313298 from LifeSpan Bioscience
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Anti-ADRA2A Antibody (aa312-361) - LS-C200099 from LifeSpan Bioscience
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Anti-ADRA2A Antibody (Arg361) - LS-C176895 from LifeSpan Bioscience
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Anti-ADRA2A Antibody (aa331-380) IHC-plus⢠- LS-B7669 from LifeSpan Bioscience
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Anti-ADRA2A Antibody (aa218-235) - LS-C20326 from LifeSpan Bioscience
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Anti-ADRA2A Antibody - LS-C20327 from LifeSpan Bioscience
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Anti-ADRA2A Antibody (aa246-258) - LS-C54454 from LifeSpan Bioscience
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Anti-ADRA2A Antibody (aa414-431) - LS-C121346 from LifeSpan Bioscience
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Anti-ADRA2A Antibody (C-Terminus) - LS-C121345 from LifeSpan Bioscience
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alpha-2A Adrenergic R/ADRA2A Antibody - NBP1-67832 from Novus Biologicals
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alpha-2A Adrenergic R/ADRA2A Antibody - NBP1-19562 from Novus Biologicals
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alpha-2A Adrenergic R/ADRA2A Antibody - NBP2-36733 from Novus Biologicals
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alpha-2A Adrenergic R/ADRA2A Antibody - NBP1-70919 from Novus Biologicals
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alpha-2A Adrenergic R/ADRA2A Antibody - NB100-2819 from Novus Biologicals
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ADRA2 Polyclonal Antibody - bs-1062R from Bioss
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