Gene Symbol | ADRA2A |
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Entrez Gene | 150 |
Alt Symbol | ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32 |
Species | Human |
Gene Type | protein-coding |
Description | adrenoceptor alpha 2A |
Other Description | adrenergic, alpha-2A-, receptor|alpha-2 adrenergic receptor subtype C10|alpha-2-adrenergic receptor, platelet type|alpha-2A adrenergic receptor|alpha-2A adrenoceptor|alpha-2A adrenoreceptor|alpha-2AAR subtype C10 |
Swissprots | Q86TH8 P08913 Q2I8G2 Q2XN99 B0LPF6 Q9BZK1 |
Accessions | AAA51664 AAA51665 AAF91441 AAG00447 AAK01634 AAK51162 AAZ73101 ABB72683 ABY87535 EAW49547 P08913 AF284095 AAK26743 BC035047 AAH35047 BC050414 AAH50414 BM682651 NM_000681 NP_000672 |
Function | Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:23105096}; Multi-pass membrane protein {ECO:0000269|PubMed:23105096}. |
Top Pathways | cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction |
Active human alpha 2a Adrenergic Receptor full length protein - ab54291 from Abcam
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alpha 2a Adrenergic Receptor peptide - ab82446 from Abcam
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alpha 2a Adrenergic Receptor peptide - ab195355 from Abcam
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alpha 2a Adrenergic Receptor peptide (246-258) - ab45883 from Abcam
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Human alpha 2a Adrenergic Receptor peptide - ab102061 from Abcam
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ADRA2A Antibody Blocking Peptide - LS-E21956 from LifeSpan Bioscience
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ADRA2A Antibody Blocking Peptide - LS-E26041 from LifeSpan Bioscience
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ZNF32 Partial Recombinant Protein - H00007580-Q01 from Novus Biologicals
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ZNF32 Recombinant Protein - H00007580-P01 from Novus Biologicals
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Recombinant Human alpha-2A Adrenergic R/ADRA2A Protein - H00000150-G01 from Novus Biologicals
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alpha 2a Adrenergic Receptor blocking peptide - GTX89396-PEP from GeneTex
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Alpha-2A Adrenergic Receptor Blocking Peptide - abx161258 from Abbexa
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alpha 2A Adrenergic Receptor Peptide - AC21-0869-P from Abcore
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Alpha-2A adrenergic receptor - H00000150-G01 from Acris Antibodies
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ADRA2A Peptide - 45-210P from ProSci
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ADRA2A fusion protein - Ag5562 from Proteintech Group
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ADRA2A fusion protein - ag5725 from Proteintech Group
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Recombinant Human ADRA2A, GST-tagged - ADRA2A-9442H from Creative Biomart
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ChemiSCREEN™ Human α 2A Adrenergic Receptor Membrane Preparation - HTS096M from EMD Millipore
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Alpha-2A Adrenergic Receptor Blocking Peptide - CBP3757 from Cohesion Biosciences
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AR-α2A (R361) Peptide - BS2254P from Bioworld Technology
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Alpha-2A adrenergic receptor (ADRA2A) - MBS1211724 from MyBioSource
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Alpha-2B adrenergic receptor (ADRA2B) - MBS958697 from MyBioSource
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ADRA2A Protein - abx163270 from Abbexa
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ADRA2A, Peptide - MBS425446 from MyBioSource
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