| Gene Symbol |
ADRA2A
|
| Entrez Gene |
150
|
| Alt Symbol |
ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adrenoceptor alpha 2A
|
| Other Description |
adrenergic, alpha-2A-, receptor|alpha-2 adrenergic receptor subtype C10|alpha-2-adrenergic receptor, platelet type|alpha-2A adrenergic receptor|alpha-2A adrenoceptor|alpha-2A adrenoreceptor|alpha-2AAR subtype C10
|
| Swissprots |
Q86TH8 P08913 Q2I8G2 Q2XN99 B0LPF6 Q9BZK1
|
| Accessions |
AAA51664 AAA51665 AAF91441 AAG00447 AAK01634 AAK51162 AAZ73101 ABB72683 ABY87535 EAW49547 P08913 AF284095 AAK26743 BC035047 AAH35047 BC050414 AAH50414 BM682651 NM_000681 NP_000672
|
| Function |
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:23105096}; Multi-pass membrane protein {ECO:0000269|PubMed:23105096}.
|
| Top Pathways |
cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction
|