| Gene Symbol | ADRA2A |
|---|---|
| Entrez Gene | 150 |
| Alt Symbol | ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32 |
| Species | Human |
| Gene Type | protein-coding |
| Description | adrenoceptor alpha 2A |
| Other Description | adrenergic, alpha-2A-, receptor|alpha-2 adrenergic receptor subtype C10|alpha-2-adrenergic receptor, platelet type|alpha-2A adrenergic receptor|alpha-2A adrenoceptor|alpha-2A adrenoreceptor|alpha-2AAR subtype C10 |
| Swissprots | Q86TH8 P08913 Q2I8G2 Q2XN99 B0LPF6 Q9BZK1 |
| Accessions | AAA51664 AAA51665 AAF91441 AAG00447 AAK01634 AAK51162 AAZ73101 ABB72683 ABY87535 EAW49547 P08913 AF284095 AAK26743 BC035047 AAH35047 BC050414 AAH50414 BM682651 NM_000681 NP_000672 |
| Function | Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:23105096}; Multi-pass membrane protein {ECO:0000269|PubMed:23105096}. |
| Top Pathways | cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction |