EFNA1

Gene Symbol	EFNA1
Entrez Gene	1942
Alt Symbol	B61, ECKLG, EFL1, EPLG1, LERK-1, LERK1, TNFAIP4
Species	Human
Gene Type	protein-coding
Description	ephrin-A1
Other Description	TNF alpha-induced protein 4|eph-related receptor tyrosine kinase ligand 1|immediate early response protein B61|ligand of eph-related kinase 1|tumor necrosis factor alpha-induced protein 4|tumor necrosis factor, alpha-induced protein 4
Swissprots	Q5SR60 D3DV86 Q8N578 Q6I9T9 Q5SR61 P20827
Accessions	CAX86883 CAX86884 EAW53131 EAW53132 EAW53133 EAW53134 EAW53135 P20827 AK057845 AK289589 BAF82278 AK308965 AK311677 AK313117 BAG35938 AL833641 AW274944 BC032698 AAH32698 BC095432 AAH95432 BC150578 CR457416 CAG33697 DQ890722 ABM81648 DQ893900 ABM84826 M57730 AAA58388 XM_005244940 XP_005244997 NM_004428 NP_004419 NM_182685 NP_872626
Function	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269|P
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18794797}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18794797}.
Tissue Specificity	Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). {ECO:0000269|PubMed:17332925}.
Top Pathways	Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EFNA1 / Ephrin A1 ELISA Kit (Sandwich ELISA) - LS-F6374 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human EFNA1 / Ephrin A1 ELISA Kit (Sandwich ELISA) - LS-F11356 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Ephrin A1, EFNA1, Human, ELISA Kit - E-EL-H0875 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Ephrin A1 (EFNA1), Human, ELISA Kit - SEE107Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.066ng/mL Range 0.156-10ng/mL

Ephrin-A1 (EFNA1), Human, ELISA Kit - CSB-EL007460HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Ephrin-A1, EFNA1, Human, ELISA Kit - E1422h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Ephrin A1, EFNA1, Rabbit, ELISA Kit - E-EL-RB1602 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ephrin A1, EFNA1, Chicken, ELISA Kit - E-EL-Ch2034 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Ephrin A1, EFNA1, Porcine, ELISA Kit - E-EL-P1436 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ephrin A1, EFNA1, Sheep, ELISA Kit - E-EL-S0792 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Ephrin A1, EFNA1, Monkey, ELISA Kit - E-EL-MK2145 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human EFNA1 ELISA Kit - HE0049 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine EFNA1 ELISA Kit - AE0049 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

ephrin-A1, ELISA Kit - MBS945015 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human EFNA1 is typically less than 0.039 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0.156 ng/ml -10 ng/ml.

Ephrin-A1, ELISA Kit - MBS283338 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human EFNA1(Ephrin A1) ELISA Kit - E-EL-H0875 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human EFNA1 (Ephrin A1) CLIA Kit - E-CL-H0607 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

EFNA1, ELISA Kit - MBS2512180 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

EFNA1, ELISA Kit - MBS2507585 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

EFNA1, ELISA Kit - MBS2509225 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

EFNA1, ELISA Kit - MBS2506414 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human EFNA1 is 0.094ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.156-10ng/mL

EFNA1, ELISA Kit - MBS2507982 from MyBioSource Category ELISA Kit Prices $490.00, $585.00, $2,475.00, $4,360.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/mL Range 0.781-50ng/mL

EFNA1, ELISA Kit - MBS2508241 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

Ephrin A1, ELISA Kit - MBS723971 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ephrin A1, ELISA Kit - MBS015110 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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