EFNA1

Gene Symbol	EFNA1
Entrez Gene	1942
Alt Symbol	B61, ECKLG, EFL1, EPLG1, LERK-1, LERK1, TNFAIP4
Species	Human
Gene Type	protein-coding
Description	ephrin-A1
Other Description	TNF alpha-induced protein 4|eph-related receptor tyrosine kinase ligand 1|immediate early response protein B61|ligand of eph-related kinase 1|tumor necrosis factor alpha-induced protein 4|tumor necrosis factor, alpha-induced protein 4
Swissprots	Q5SR60 D3DV86 Q8N578 Q6I9T9 Q5SR61 P20827
Accessions	CAX86883 CAX86884 EAW53131 EAW53132 EAW53133 EAW53134 EAW53135 P20827 AK057845 AK289589 BAF82278 AK308965 AK311677 AK313117 BAG35938 AL833641 AW274944 BC032698 AAH32698 BC095432 AAH95432 BC150578 CR457416 CAG33697 DQ890722 ABM81648 DQ893900 ABM84826 M57730 AAA58388 XM_005244940 XP_005244997 NM_004428 NP_004419 NM_182685 NP_872626
Function	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269|P
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18794797}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18794797}.
Tissue Specificity	Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). {ECO:0000269|PubMed:17332925}.
Top Pathways	Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EFNA1-Over-expression-Lysate - LY12518a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

EFNA1 overexpression lysate - LY401408 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

EFNA1 overexpression lysate - LY405448 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

EFNA1 293 Cell Lysate - 403603 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

EFNA1 293 Cell Lysate - 401282 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Ephrin-A1 Overexpression Lysate (Native) - NBL1-10142 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ephrin-A1 (h): 293T Lysate - sc-111528 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

ephrin-A1 (h2): 293T Lysate - sc-115172 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

ephrin-A1 (h4): 293T Lysate - sc-110114 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

EFNA1 Over-expression Lysate Product - GWB-C3F078 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

EFNA1 Over-expression Lysate Product - GWB-1F70CC from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human Ephrin-A1 / EFNA1 HEK293 Cell Lysate (WB positive control) - 10882-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Ephrin-A1 / EFNA1 HEK293 Cell Lysate (WB positive control) - 10882-H03HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Ephrin-A1 Overexpression Lysate (Native) - NBP2-04832 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Ephrin-A1 Overexpression Lysate (Denatured) - H00001942-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human EFNA1 Human Cells Transfected Lysate (positive control) (denatured) - orb173236 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human EFNA1 Human Cells Transfected Lysate (positive control) (denatured) - orb173111 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human EFNA1 Knockdown Stable Cell Line - CSC-DC004754 from Creative biogene Category Cell Line Species Human

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