EFNA1

Gene Symbol EFNA1
Entrez Gene 1942
Alt Symbol B61, ECKLG, EFL1, EPLG1, LERK-1, LERK1, TNFAIP4
Species Human
Gene Type protein-coding
Description ephrin-A1
Other Description TNF alpha-induced protein 4|eph-related receptor tyrosine kinase ligand 1|immediate early response protein B61|ligand of eph-related kinase 1|tumor necrosis factor alpha-induced protein 4|tumor necrosis factor, alpha-induced protein 4
Swissprots Q5SR60 D3DV86 Q8N578 Q6I9T9 Q5SR61 P20827
Accessions CAX86883 CAX86884 EAW53131 EAW53132 EAW53133 EAW53134 EAW53135 P20827 AK057845 AK289589 BAF82278 AK308965 AK311677 AK313117 BAG35938 AL833641 AW274944 BC032698 AAH32698 BC095432 AAH95432 BC150578 CR457416 CAG33697 DQ890722 ABM81648 DQ893900 ABM84826 M57730 AAA58388 XM_005244940 XP_005244997 NM_004428 NP_004419 NM_182685 NP_872626
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269|P
Subcellular Location Cell membrane {ECO:0000269|PubMed:18794797}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18794797}.
Tissue Specificity Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). {ECO:0000269|PubMed:17332925}.
Top Pathways Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway

ephrin-A1 (B-12) - sc-377165 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ephrin-A1 (B-12): sc-377165. Western blot analysis of ephrin-A1 expression in non-transfected: sc-117752 (A) and human ephrin-A1 transfected: sc-111528 (B) 293T whole cell lysates.

ephrin-A1 (A-5) - sc-377362 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ephrin-A1 (A-5): sc-377362. Western blot analysis of ephrin-A1 expression in non-transfected: sc-117752 (A) and human ephrin-A1 transfected: sc-111528 (B) 293T whole cell lysates.

ephrin-A1 (H-60) - sc-20719 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ephrin-A1 (H-60): sc-20719. Western blot analysis of ephrin-A1 expression in non-transfected: sc-117752 (A) and human ephrin-A1 transfected: sc-111528 (B) 293T whole cell lysates.

ephrin-A1 (V-18) - sc-911 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ephrin-A1 (V-18): sc-911. Western blot analysis of ephrin-A1 expression in non-transfected: sc-117752 (A) and human ephrin-A1 transfected: sc-111528 (B) 293T whole cell lysates.

Anti-Ephrin A1 antibody - ab65072 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ephrin A1 antibody (ab65072) at 1/500 dilutionLane 1 : extracts from 293 cellsLane 2 : extracts from Jurkat cellsLane 3 : extracts from Jurkat cells with immunizing peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-Ephrin A1 antibody - ab199697 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of HeLa cells labeling Ephrin A1 with ab199697 at 1/100 dilution. Right panel shows the negative control.

Anti-Ephrin A1 antibody - ab109581 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Ephrin A1 antibody (ab109581) at 0.01 µg/ml + Mouse Thymus lysate (in RIPA buffer) at 35 µg

Anti-Ephrin A1 antibody - ab97527 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Ephrin A1 antibody (ab97527) at 1/1000 dilution + Hep G2 whole cell lysate at 30 µg

Anti-Ephrin A1 antibody [EPR1785(2)] - ab124911 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1785(2)
All lanes : Anti-Ephrin A1 antibody [EPR1785(2)] (ab124911) at 1/1000 dilutionLane 1 : HUVEC cell lysate, treated with TNF alphaLane 2 : HUVEC cell lysateLane 3 : MCF7 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-Ephrin A1 antibody [EPR1786(2)] - ab133598 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1786(2)
All lanes : Anti-Ephrin A1 antibody [EPR1786(2)] (ab133598) at 1/1000 dilutionLane 1 : HUVEC cell lysate treated with TNF alphaLane 2 : HUVEC cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-EFNA1 / Ephrin A1 Antibody (C-Terminus) - LS-C6529 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EFNA1 / Ephrin A1 Antibody (aa1-205) - LS-C185511 from LifeSpan Bioscience

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EFNA1 / Ephrin A1 Antibody - LS-C285492 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EFNA1 / Ephrin A1 Antibody (HRP) - LS-C317194 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EFNA1 / Ephrin A1 Antibody (Biotin) - LS-C318832 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EFNA1 / Ephrin A1 Antibody (FITC) - LS-C317195 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EFNA1 / Ephrin A1 Antibody - LS-C341198 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EFNA1 / Ephrin A1 Antibody (aa144-155) - LS-C139668 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
EFNA1 antibody (0.01 ug/ml) staining of Mouse Thymus lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-EFNA1 / Ephrin A1 Antibody (Internal, clone EPR1786(2)) - LS-C138997 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1786(2)
Western blot analysis on (A) HUVEC cell treated with TNF alpha and (B) HUVEC cell lysates using anti-Ephrin-A1 antibody.

Anti-EFNA1 / Ephrin A1 Antibody (N-Terminus, clone EPR1785(2)) - LS-C138647 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1785(2)
Western blot analysis on (A) HUVEC treated with TNF-alpha, (B) HUVEC, and (C) MCF-7 cell lysates using anti-Ephrin-A1 antibody.

Anti-EFNA1 / Ephrin A1 Antibody - LS-C335561 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using EFNA1 antibody.

Anti-EFNA1 / Ephrin A1 Antibody (aa66-115) IHC-plus™ - LS-B9141 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human, Brain, Cerebellum: Formalin-Fixed Paraffin-Embedded (FFPE)

Anti-EFNA1 / Ephrin A1 Antibody - LS-C311111 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EFNA1 / Ephrin A1 Antibody (Lys98) - LS-C176745 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of Ephrin-A1 (K98) pAb in paraffin-embedded human heart tissue.

Ephrin-A1 Antibody - NBP1-30503 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Ephrin A1 Antibody [NBP1-30503] - Extracts from THP1 cells.
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