KIF7

Gene Symbol KIF7
Entrez Gene 374654
Alt Symbol ACLS, HLS2, JBTS12, UNQ340
Species Human
Gene Type protein-coding
Description kinesin family member 7
Other Description EQYK340|kinesin-like protein KIF7
Swissprots Q3SXY0 Q2M1P5 Q8IW72 Q6UXE9
Accessions EAX02057 Q2M1P5 AW451733 AY358384 AAQ88750 BC040878 AAH40878 BC042063 BC104044 AAI04045 BC112271 AAI12272 BC112273 AAI12274 BC143461 AAI43462 XM_005254902 XP_005254959 XM_011521531 XP_011519833 XM_011521532 XP_011519834 XM_011521533 XP_011519835 XM_011521534 XP_011519836 XM_011521535 XP_011519837 XM_011521536 XP_011519838 XM_011521537 XP_011519839 NM_198525 NP_940927
Function Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {
Subcellular Location Cell projection, cilium {ECO:0000269|PubMed:19592253}. Note=Localizes to the cilium tip.
Tissue Specificity Embryonic stem cells, melanotic melanoma and Jurkat T-cells. Expressed in heart, lung, liver, kidney, testis, retina, placenta, pancreas, colon, small intestin, prostate and thymus. {ECO:0000269|PubMed:21633164}.

KIF7 (C-17) - sc-107667 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-KIF7 antibody - ab95884 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KIF7 antibody (ab95884) at 0.4 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-KIF7 Antibody (aa1225-1275) - LS-C289428 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KIF7 Antibody (aa1266-1315) - LS-C187257 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HT1080. KIF7 antibody dilution 1.0 ug/ml.

Anti-KIF7 Antibody (aa1224-1273) - LS-C146000 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KIF7 antibody LS-C146000 Western blot of A549 Cell lysate. Antibody concentration 1 ug/ml.

KIF7 Antibody - NBP1-46838 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: KIF7 Antibody [NBP1-46838] - Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 ug) cells. Antibody used at 0.4 ug/ml.

KIF7 Antibody - NBP1-92056 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: KIF7 Antibody [NBP1-92056] - Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.

KIF7 Polyclonal Antibody - bs-12388R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Paraformaldehyde-fixed, paraffin embedded mouse brain; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with KIF7 Polyclonal Antibody, Unconjugated (bs-12388R)at 1:200 overnight at 4°C, followed by a conjugated secondary and DAB staining.

KIF7 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12388R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KIF7 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12388R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KIF7 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12388R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KIF7 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12388R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KIF7 Polyclonal Antibody, Cy3 Conjugated - bs-12388R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KIF7 Polyclonal Antibody, Cy5 Conjugated - bs-12388R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KIF7 Polyclonal Antibody, Cy5.5 Conjugated - bs-12388R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KIF7 Polyclonal Antibody, Cy7 Conjugated - bs-12388R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KIF7 Polyclonal Antibody, FITC Conjugated - bs-12388R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KIF7 Polyclonal Antibody, Biotin Conjugated - bs-12388R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KIF7 Polyclonal Antibody, HRP Conjugated - bs-12388R-HRP from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KIF7 antibody produced in rabbit - HPA043145 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-KIF7: <B>Cat. No. HPA043145</B>: Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.

Anti-KIF7 antibody produced in rabbit - SAB2107672 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KIF7: <B>Cat. No. SAB2107672</B>: Western blot analysis of KIF7 in A549 with KIF7 (kinesin family member 7) antibody against the C terminal of KIF7 (50 μg) antibody at 1.0 μg/mL.

KIF7 antibody - C-terminal region (ARP62008_P050) - ARP62008_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KIF7 Antibody - C-terminal region (ARP62009_P050) - ARP62009_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HCII antibody - 20R-1392 from Fitzgerald

Prices $220.00
Sizes 5 mg
Host Goat
Clonality Polyclonal

Anti -GLi3 (GLI-Kruppel Family Member GLI3) - G2035-54A from USBiological Life Science

Host Rabbit
Clonality Polyclonal
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