| Gene Symbol |
KIF7
|
| Entrez Gene |
374654
|
| Alt Symbol |
ACLS, HLS2, JBTS12, UNQ340
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kinesin family member 7
|
| Other Description |
EQYK340|kinesin-like protein KIF7
|
| Swissprots |
Q3SXY0 Q2M1P5 Q8IW72 Q6UXE9
|
| Accessions |
EAX02057 Q2M1P5 AW451733 AY358384 AAQ88750 BC040878 AAH40878 BC042063 BC104044 AAI04045 BC112271 AAI12272 BC112273 AAI12274 BC143461 AAI43462 XM_005254902 XP_005254959 XM_011521531 XP_011519833 XM_011521532 XP_011519834 XM_011521533 XP_011519835 XM_011521534 XP_011519836 XM_011521535 XP_011519837 XM_011521536 XP_011519838 XM_011521537 XP_011519839 NM_198525 NP_940927
|
| Function |
Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {
|
| Subcellular Location |
Cell projection, cilium {ECO:0000269|PubMed:19592253}. Note=Localizes to the cilium tip.
|
| Tissue Specificity |
Embryonic stem cells, melanotic melanoma and Jurkat T-cells. Expressed in heart, lung, liver, kidney, testis, retina, placenta, pancreas, colon, small intestin, prostate and thymus. {ECO:0000269|PubMed:21633164}.
|