KIF7

Gene Symbol KIF7
Entrez Gene 374654
Alt Symbol ACLS, HLS2, JBTS12, UNQ340
Species Human
Gene Type protein-coding
Description kinesin family member 7
Other Description EQYK340|kinesin-like protein KIF7
Swissprots Q3SXY0 Q2M1P5 Q8IW72 Q6UXE9
Accessions EAX02057 Q2M1P5 AW451733 AY358384 AAQ88750 BC040878 AAH40878 BC042063 BC104044 AAI04045 BC112271 AAI12272 BC112273 AAI12274 BC143461 AAI43462 XM_005254902 XP_005254959 XM_011521531 XP_011519833 XM_011521532 XP_011519834 XM_011521533 XP_011519835 XM_011521534 XP_011519836 XM_011521535 XP_011519837 XM_011521536 XP_011519838 XM_011521537 XP_011519839 NM_198525 NP_940927
Function Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {
Subcellular Location Cell projection, cilium {ECO:0000269|PubMed:19592253}. Note=Localizes to the cilium tip.
Tissue Specificity Embryonic stem cells, melanotic melanoma and Jurkat T-cells. Expressed in heart, lung, liver, kidney, testis, retina, placenta, pancreas, colon, small intestin, prostate and thymus. {ECO:0000269|PubMed:21633164}.

KIF7 CRISPR/Cas9 KO Plasmid (h) - sc-407218 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF7 HDR Plasmid (h) - sc-407218-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF7 Double Nickase Plasmid (h) - sc-407218-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF7 Double Nickase Plasmid (h2) - sc-407218-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF7 CRISPR Activation Plasmid (h) - sc-407218-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF7 CRISPR Activation Plasmid (h2) - sc-407218-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF7 Lentiviral Activation Particles (h) - sc-407218-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF7 Lentiviral Activation Particles (h2) - sc-407218-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIF7 siRNA (h) - sc-89962 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KIF7 shRNA Plasmid (h) - sc-89962-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KIF7 shRNA (h) Lentiviral Particles - sc-89962-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU016611 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11208 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11208 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03821 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03821

KIF7 siRNA (Human) - CRJ7623 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KIF7 (NM_198525.2) - SHH325395 from Creative biogene

Category siRNA
Species Reactivities Human

Human KIF7 siRNA - orb278124 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KIF7 shRNA Plasmid (Human) - CHJ7623 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KIF7 miRNA 3'UTR clone - MiUTR3H-11751 from Creative biogene

Species Reactivities Human
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