| Gene Symbol | AGAP3 |
|---|---|
| Entrez Gene | 116988 |
| Alt Symbol | AGAP-3, CENTG3, CRAG, MRIP-1, cnt-g3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 |
| Other Description | CRAM-associated GTPase|CRMP (collapsin response mediator protein) associated|MR1-interacting protein|arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3|centaurin, gamma 3|centaurin-gamma-3 |
| Swissprots | E9PAL8 Q96P47 Q96RK3 Q59EN0 B3KNZ8 |
| Accessions | CCQ43753 EAL24502 EAW54024 EAW54025 EAW54026 EAW54027 EAW54028 EAW54029 Q96P47 AB209781 BAD93018 AF359283 AAK48932 AF413079 AAL04173 AK027415 BAB55097 AK055393 BAG51510 AK091771 AK096352 BAC04766 AL442089 CAC09448 BC020426 BC037543 BC044644 AAH44644 BC048300 AAH48300 BC069236 BU615528 DA771207 EU831441 ACE87128 EU831533 ACE86452 XM_005249942 XP_005249999 XM_005249943 XP_005250000 XM_011515780 XP_011514082 NM_001042535 NP_001036000 NM_001281300 NP_001268229 NM_001308304 NP_001295233 NM_001308305 NP_001295234 NM_031946 NP_114152 |
| Function | GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:16461359, ECO:0000305}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16461359}. Note=In cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:15381706, ECO:0000269|PubMed:16461359}. |
| Top Pathways | Endocytosis |
Centaurin γ3 CRISPR/Cas9 KO Plasmid (h) - sc-409017 from Santa Cruz Biotechnology
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Centaurin γ3 HDR Plasmid (h) - sc-409017-HDR from Santa Cruz Biotechnology
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Centaurin γ3 Double Nickase Plasmid (h) - sc-409017-NIC from Santa Cruz Biotechnology
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Centaurin γ3 Double Nickase Plasmid (h2) - sc-409017-NIC-2 from Santa Cruz Biotechnology
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Centaurin γ3 CRISPR Activation Plasmid (h) - sc-409017-ACT from Santa Cruz Biotechnology
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Centaurin γ3 CRISPR Activation Plasmid (h2) - sc-409017-ACT-2 from Santa Cruz Biotechnology
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Centaurin γ3 Lentiviral Activation Particles (h) - sc-409017-LAC from Santa Cruz Biotechnology
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Centaurin γ3 Lentiviral Activation Particles (h2) - sc-409017-LAC-2 from Santa Cruz Biotechnology
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Centaurin γ3 siRNA (h) - sc-60355 from Santa Cruz Biotechnology
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Centaurin γ3 shRNA Plasmid (h) - sc-60355-SH from Santa Cruz Biotechnology
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Centaurin γ3 shRNA (h) Lentiviral Particles - sc-60355-V from Santa Cruz Biotechnology
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AGAP3 RNAi - H00116988-R01 from Novus Biologicals
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MISSION® esiRNA - EHU134261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2929 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2929 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03949 from Sigma-Aldrich
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AGAP3 siRNA (Human) - CRJ4546 from Cohesion Biosciences
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AGAP3 - MBS8234406 from MyBioSource
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shRNA set against Human AGAP3 (NM_031946.4) - SHH233138 from Creative biogene
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shRNA set against Human CENTG3(NM_001042535.1) - SHG031717 from Creative biogene
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shRNA set against Human CENTG3(NM_031946.4) - SHG031735 from Creative biogene
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Human AGAP3 siRNA - orb275047 from Biorbyt
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AGAP3 shRNA Plasmid (Human) - CHJ4546 from Cohesion Biosciences
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AGAP3 miRNA 3'UTR clone - MiUTR1H-02048 from Creative biogene
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AGAP3 miRNA 3'UTR clone - MiUTR3H-13526 from Creative biogene
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