| Gene Symbol |
RAP2A
|
| Entrez Gene |
5911
|
| Alt Symbol |
K-REV, KREV, RAP2, RbBP-30
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAP2A, member of RAS oncogene family
|
| Other Description |
RAP2, member of RAS oncogene family (K-rev)|ras-related protein Rap-2a
|
| Swissprots |
P10114 Q5JSC1 Q5JSC2 B2RCJ1
|
| Accessions |
CAA00806 EAX08974 P10114 AF205602 AAN71845 AF493914 AAM12628 AK090533 AK094586 AK311202 AK315139 BAG37588 BC022356 BC041333 AAH41333 BC047495 BC070031 AAH70031 CB215818 DA493957 DB480985 EU832309 ACE87566 EU832393 ACE86878 X12534 CAA31052 NM_021033 NP_066361
|
| Function |
Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. {ECO:0000269|PubMed:14966141, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:16246175, ECO:0000269|PubMed:16540189, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:20159449}.
|
| Subcellular Location |
Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=May also localize to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995). Colocalizes with RASGEF1B to midbody at telophase (PubMed:23894443). {ECO:0000269|PubMed:23894443, ECO:0000269|PubMed:7962206, ECO:0000269|PubMed:8391995}.
|