FCGR2B

Gene Symbol FCGR2B
Entrez Gene 2213
Alt Symbol CD32, CD32B, FCG2, FCGR2, IGFR2
Species Human
Gene Type protein-coding
Description Fc fragment of IgG, low affinity IIb, receptor (CD32)
Other Description CDw32|Fc fragment of IgG, low affinity II, receptor for (CD32)|Fc fragment of IgG, low affinity IIb, receptor for (CD32)|Fc gamma RIIb|fc-gamma RII-b|fc-gamma-RIIb|fcRII-b|igG Fc receptor II-b|low affinity immunoglobulin gamma Fc region receptor II-b
Swissprots Q5VXA9 O95649 P31994 Q53X85 A6H8N3 Q8NIA1
Accessions ABK41919 BAC54013 BAC54014 BAC54015 BAC54016 BAC54017 BAC54018 BAC54019 BAC54020 EAW90679 EAW90680 EAW90681 EAW90682 P31994 AB050934 BAB92093 AB051387 BAB92094 AB209585 BAD92822 AF543826 AAQ11739 AI692546 AK308150 AW452813 BC031992 AAH31992 BC141826 AAI41827 BC146678 AAI46679 BC148273 AAI48274 CB988406 CR407635 CAG28563 DC381078 DQ894525 ABM85451 H04104 M28696 AAA36051 M31933 AAA35841 M31934 AAA35842 M31935 AAA35843 U87560 AAD00627 U87561 AAD00628 U87562 AAD00629 U87563 AAD00630 U87564 AAD00631 U87565 AAD00632 U87566 AAD00633 U87567 AAD00634 U87568 AAD00635 U87569 AAD00636 U87570 AAD00637 U87571 AAD00638 U87572 AAD00639 U87573 AAD00640 U87574 AAD00641 U87575 AAD00642 U87576 AAD00643 U87577 AAD00644 X17653 CAA35644 X52473 CAA36713 X62573 XM_011509292 XP_011507594 NM_001002273 NP_001002273 NM_001002274 NP_001002274 NM_001002275 NP_001002275 NM_001190828 NP_001177757 NM_004001 NP_003992
Function Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
Top Pathways B cell receptor signaling pathway, Fc gamma R-mediated phagocytosis, Phagosome, Staphylococcus aureus infection, Osteoclast differentiation

Phospho-CD32 (FcgammaRIIb) (Tyr292) Antibody - 4141 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from control or CD32 crosslinked human THP.1 or Raji cell lines, using Phospho-CD32 (FcgammaRIIb) (Tyr292) Antibody.

CD32 (AT10) - sc-13527 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD32 (AT10) Alexa Fluor 488: sc-13527 AF488. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG1: sc-3890.

CD32 (FL-285) - sc-28842 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CD32 (FL-285): sc-28842. Western blot analysis of CD32 expression in U-698-M whole cell lysate.

CD32 (KB61) - sc-20054 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD32 (KB61) PE: sc-20054 PE. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

CD32-B (F-4) - sc-365864 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD32-B (F-4): sc-365864. Western blot analysis of CD32 expression in non-transfected: sc-117752 (A) and human CD32 transfected: sc-112622 (B) 293T whole cell lysates.

CD32-B (C-20) - sc-12815 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD32-B (C-20): sc-12815. Western blot analysis of CD32-B expression in non-transfected: sc-117752 (A) and human CD32-B transfected: sc-113838 (B) 293T whole cell lysates.

CD32-B/Fc γ RIIb (E-16) - sc-13271 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD32-B/Fc γ RIIb (E-16): sc-13271. Western blot analysis of CD32-B/Fc γ RIIb expression in non-transfected: sc-117752 (A) and human CD32-B transfected: sc-113838 (B) 293T whole cell lysates.

Anti-CD32B (phospho Y292) antibody - ab74092 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD32B (phospho Y292) antibody (ab74092) at 1/500 dilutionLane 1 : K562 cell extracts treated with PMA (125ng/ml, 30mins)Lane 2 : K562 cell extracts treated with PMA (125ng/ml, 30mins) with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-CD32B antibody - ab110076 from Abcam

Prices $384.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-CD32B antibody (ab110076) at 0.3 µg/ml + K562 lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-CD32B antibody - ab77093 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-CD32B antibody (ab77093) at 0.3 µg/ml + K562 lysate at 35 µgdeveloped using the ECL technique

Anti-CD32B antibody - ab123240 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CD32B antibody (ab123240) at 1 µg/ml + Human fetal lung lysate at 10 µgSecondaryGoat anti-Rabbit IgG HRP

Anti-CD32B antibody - ab168799 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD32B antibody (ab168799) at 1 µg/mlLane 1 : CD32B transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-CD32B antibody [EP888Y] - ab45143 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP888Y
Anti-CD32B antibody [EP888Y] (ab45143) at 1/50000 dilution + 10 ug Daudi cell lysate SecondaryGoat anti rabbit HRP 1/2000Observed band size : 49-55 kDa (why is the actual band size different from the predicted?).

Anti-CD32B antibody - C-terminal - ab151497 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab151497 staining CD32B in Human basophil cells by Flow Cytometry. The sample was incubated with the primary antibody (10µg/ml in MACS) for 30 minutes at 4°C. An undiluted phycoerythrin-conjugated Donkey anti-rabbit IgG was used as the secondary antibody.See Abreview

Anti-FCGR2 / CD32 Antibody (phospho-Tyr292, clone EP926Y) - LS-C50221 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP926Y
Western blot analysis on Daudi cell lysates using anti-Phospho-Fc gamma RIIb (py292) antibody, 1:100000 dilution. Cells were either (A) untreated (B) treated with pervanadate.

Anti-CD32B Antibody (aa249-279, AP) - LS-C246941 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CD32B Antibody (aa249-279, PE) - LS-C235261 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CD32B Antibody (C-Terminus) - LS-C146182 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FCGR2B / CD32B antibody LS-C146182 Western blot of Fetal Lung lysate. Antibody concentration 1 ug/ml.

Anti-CD32B Antibody (aa249-279, APC) - LS-C246942 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CD32B Antibody (aa249-279, Biotin) - LS-C246943 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CD32B Antibody (C-Terminus) - LS-C146183 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FCGR2B / CD32B antibody LS-C146183 Western blot of Placenta lysate. Antibody concentration 1 ug/ml.

Anti-CD32B Antibody (aa249-279, FITC) - LS-C246944 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CD32B Antibody (aa249-279, Azide-free, HRP) - LS-C249982 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CD32B Antibody (aa45-155) - LS-C309256 from LifeSpan Bioscience

Prices $620.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-CD32B Antibody (phospho-Tyr292) - LS-C313571 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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