| Gene Symbol |
AKR1D1
|
| Entrez Gene |
6718
|
| Alt Symbol |
3o5bred, CBAS2, SRD5B1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aldo-keto reductase family 1, member D1
|
| Other Description |
3-oxo-5-beta-steroid 4-dehydrogenase|delta 4-3-ketosteroid-5-beta-reductase|delta(4)-3-ketosteroid 5-beta-reductase|delta(4)-3-oxosteroid 5-beta-reductase|steroid-5-beta-reductase, beta polypeptide 1 (3-oxo-5 beta-steroid delta 4-dehydrogenase beta 1)
|
| Swissprots |
P51857 A1L4P6 B4DPN8 B4DPN3 A8K060
|
| Accessions |
AAG39381 EAL24049 EAW83881 EAW83882 P51857 AK058142 BAB71682 AK289425 BAF82114 AK298421 BAG60645 AK298428 BAG60650 BC130625 AAI30626 BC130627 AAI30628 BG210362 CB111926 FM160741 CAQ55951 FM160742 CAQ55952 FM160743 CAQ55953 HQ258384 ADR83138 Z28339 CAA82193 NM_001190906 NP_001177835 NM_001190907 NP_001177836 NM_005989 NP_005980
|
| Function |
Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates. {ECO:0000269|PubMed:11342103}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Highly expressed in liver. Expressed in testis and weakly in colon. {ECO:0000269|PubMed:11342103}.
|
| Top Pathways |
Primary bile acid biosynthesis, Steroid hormone biosynthesis
|